ArticleJournal of Taibah University Medical Sciences2019
Determining the effect of folate diets during pregnancy and lactation on neurobehavioural changes in the adult life of offspring.
Article in Journal of Taibah University Medical Sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.
- Pooled it
- Dietary Vitamin B Complex: Orchestration in Human Nutrition throughout Life with Sex Differences.Nutrients · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesAnimal and human studies have demonstrated that folic acid (FA) is essential for nervous system and brain development. In humans, insufficient maternal FA intake is known to cause neural tube defects, autism spectrum, and other neurodevelopmental disorders in children. The present study aimed to determine the impact of maternal FA supplementation on psychomotor skills and learning and memory functions in their adult offspring.
methodsEighteen female Wistar rats were randomly divided into three groups. The animals were fed three different concentrations of FA from preconception to pregnancy and during lactation. The adult offspring were assessed for neurobehavioural changes and histological confirmation by hippocampal neuron quantification.
resultsNeurobehavioural assessment revealed a significantly smaller number of alternations, a higher percentage bias, and a greater number of working and reference memory errors. The increased time spent in the dark compartment in the FA-supplementation group indicated deficit(s) in learning memory. Hippocampal neuron quantification revealed a higher mean number of viable neurons in the
conclusionResults of this investigation support the possible negative effect of high levels of maternal FA supplementation during pregnancy and lactation. Such alterations potentially lead to neurobehavioural changes in the adult offspring of Wistar rats.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.