Evidence map›Paper›PMID 31913773›Full record

ReviewViral immunology2020

Gammaherpesviruses and B Cells: A Relationship That Lasts a Lifetime.

Kaitlin E Johnson, Vera L Tarakanova

Open access · greenAbstract readReview
In one paragraph

Review in Viral immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kaitlin E JohnsonDepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Vera L TarakanovaDepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Medical College of Wisconsin · US

Funding

IRF-1: a brake to limit gammaherpesvirus infection and pathogenesisR01CA203923 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI TARAKANOVA, VERA L. · 2017 to 2021
$2.0M
Not just acute: IRF-7 has two site-specific functions against chronic gammaherpesvirus infectionF31CA243364 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI JOHNSON, KAITLIN E · 2019 to 2020
$45k
NCI NIH HHS F31 CA243364NCI NIH HHS R01 CA203923
6 · The paper itself

Abstract

Gammaherpesviruses are highly prevalent pathogens that establish life-long infection and are associated with diverse malignancies, including lymphoproliferative diseases and B cell lymphomas. Unlike other viruses that either do not infect B cells or infect B cells transiently, gammaherpesviruses manipulate physiological B cell differentiation to establish life-long infection in memory B cells. Disruption of such viral manipulation by genetic or environmental causes is likely to seed viral lymphomagenesis. In this review, we discuss physiological and unique host and viral mechanisms usurped by gammaherpesviruses to fine tune host B cell biology for optimal infection establishment and maintenance.

Indexed as

B-LymphocytesCell DifferentiationGammaherpesvirinaeHerpesviridae InfectionsHost-Pathogen InteractionsHumansLymphocyte ActivationViral ProteinsViral ProteinsB cell differentiationchronic infectiongammaherpesvirusgerminal center responselatency

Identifiers

PMID31913773
PMCPMC7247026
OpenAlexW2999245716

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.