Evidence map›Paper›PMID 31916069›Full record

ArticleCellular and molecular neurobiology2020

Overexpression of miR-124 Protects Against Neurological Dysfunction Induced by Neonatal Hypoxic-Ischemic Brain Injury.

Liulin Xiong, Haoli Zhou, Qiong Zhao, Lulu Xue, Mohammed Al-Hawwas, Jingyuan He, Maxiu Wu, Yu Zou, Mingan Yang, Jing Dai and 2 more

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
5.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Liulin Xiong *Department of Anesthesiology, The Affiliated Hospital of Zunyi Medical University, Zunyi, 563000, Guizhou, China.ORCID http://orcid.org/0000-0002-1623-5969
Haoli Zhou *The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Qiong ZhaoDepartment of Anesthesiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, Guangdong, China.
Lulu XueThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Mohammed Al-HawwasSchool of Pharmacy and Medical Sciences, Faculty of Health Sciences, University of South Australia, Adelaide, SA, 5000, Australia.
Jingyuan HeInstitute of Neuroscience, Animal Zoology Department, Kunming Medical University, Kunming, 650031, China.
Maxiu WuThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Yu ZouThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Mingan YangDivision of Biostatistics and Epidemiology, School of Public Health, San Diego State University, San Diego, 92182, USA.
Jing DaiThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Manxi He *The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, 611731, China. 2357622298@qq.com.
Tinghua Wang *Department of Anesthesiology, The Affiliated Hospital of Zunyi Medical University, Zunyi, 563000, Guizhou, China. tinghua_neuron@263.net.
University of Electronic Science and Technology of China · CNUniversity of South Australia · AUKunming Medical University · CNSan Diego State University · USSun Yat-sen University · CN

Funding

National Natural Science Foundation of China 81471268National Natural Science Foundation of China 81660193National Natural Science Foundation of China 81960214Program Innovative Research Team in Science and Technology in Yunnan province 2017HC007Research Fund for the Doctoral Program of Liu-Liu Xiong 201903
6 · The paper itself

Abstract

Neonatal hypoxic-ischemic encephalopathy (HIE) is a major cause of lifelong disabilities worldwide, without effective therapies and clear regulatory mechanisms. MicroRNAs (miRNAs) act as a significant regulator in neuroregeneration and neuronal apoptosis, thus holding great potential as therapeutic targets in HIE. In this study, we established the hypoxia-ischemia (HI) model in vivo and oxygen-glucose deprivation (OGD) model in vitro. Zea-longa score and magnetic resonance imaging were applied to verify HI-induced neuronal dysfunction and brain infarction. Subsequently, a miRNA microarray analysis was employed to profile miRNA transcriptomes. Down-regulated miR-124 was found 24 h after HIE, which corresponded to the change in PC12, SHSY5Y, and neurons after OGD. To determine the function of miR-124, mimics and lentivirus-mediated overexpression were used to regulate miR-124 in vivo and in vitro, respectively. Our results showed that miR-124 overexpression obviously promoted cell survival and suppressed neuronal apoptosis. Further, the memory and neurological function of rats was also obviously improved at 1 and 2 months after HI, indicated by the neurological severity score, Y-maze test, open field test, and rotating rod test. Our findings showed that overexpression of miR-124 can be a promising new strategy for HIE therapy in future clinical practice.

Indexed as

AnimalsDiagnostic Techniques, NeurologicalEncephalitisFetal HypoxiaGlucoseHypoxia-Ischemia, BrainMicroRNAsPC12 CellsRatsRats, Sprague-DawleyGlucoseMicroRNAsMIRN124 microRNA, ratHypoxic–ischemic encephalopathymiR-124Neuron damageNeuron survivalOxygen–glucose deprivation

Identifiers

PMID31916069
PMCPMC11448850
OpenAlexW3000442649

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.