Evidence map›Paper›PMID 31921393›Full record

ReviewComputational and structural biotechnology journal2019

G Protein-Coupled Receptor Systems and Their Role in Cellular Senescence.

Paula Santos-Otte, Hanne Leysen, Jaana van Gastel, Jhana O Hendrickx, Bronwen Martin, Stuart Maudsley

Open access · goldAbstract readReview
In one paragraph

Review in Computational and structural biotechnology journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. G protein-coupled receptor digital twins for precision and personalized medicine.Computational and structural biotechnology journal · 2025
    Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. The Relaxin-3 Receptor, RXFP3, Is a Modulator of Aging-Related Disease.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Paula Santos-OtteCenter for Molecular and Cellular Bioengineering (CMCB), Technische Universität Dresden, 01062 Dresden, Germany.
Hanne LeysenReceptor Biology Lab, University of Antwerp, 2610 Antwerp, Belgium.
Jaana van GastelReceptor Biology Lab, University of Antwerp, 2610 Antwerp, Belgium.
Jhana O HendrickxReceptor Biology Lab, University of Antwerp, 2610 Antwerp, Belgium.
Bronwen MartinReceptor Biology Lab, University of Antwerp, 2610 Antwerp, Belgium.
Stuart MaudsleyReceptor Biology Lab, University of Antwerp, 2610 Antwerp, Belgium.
University of Antwerp · BECenter for Systems Biology Dresden · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging is a complex biological process that is inevitable for nearly all organisms. Aging is the strongest risk factor for development of multiple neurodegenerative disorders, cancer and cardiovascular disorders. Age-related disease conditions are mainly caused by the progressive degradation of the integrity of communication systems within and between organs. This is in part mediated by,

Indexed as

active state, (R*)ADP-ribosylation factor GTPase-activating protein, (Arf-GAP)AgingAngiotensin II, (Ang II)angiotensin type 1 receptor, (AT1R)angiotensin type 2 receptor, (AT2R)AT1R blockers, (ARB)Ataxia telangiectasia mutated, (ATM)beta2-adrenergic receptor, (β2AR)Cellular senescencecyclin-dependent kinase 2, (CDK2)cyclin-dependent kinase inhibitor 1, (cdkn1A/p21)endothelial cell differentiation gene, (Edg)G protein-coupled receptor kinase, (GRK)G protein-coupled receptor kinase interacting protein 2 (GIT2)G protein-coupled receptor kinase interacting protein 2, (GIT2)G protein-coupled receptors (GPCRs)G protein-coupled receptors, (GPCRs)Hutchinson–Gilford progeria syndrome, (HGPS)inactive state, (R)latent semantic indexing, (LSI)Lysophosphatidic acid, (LPA)mitogen-activated protein kinase, (MAPK)nuclear factor kappa-light-chain-enhancer of activated B cells, (NF- κβ)protein kinases, (PK)purinergic receptors family, (P2Y)Regulator of G-protein signaling, (RGS)Relaxin family receptor 3, (RXFP3)renin-angiotensin system, (RAS)retinoblastoma, (RB)senescence associated secretory phenotype, (SASP)stress-induced premature senescence, (SIPS)transcription factor E2F3, (E2F3)transmembrane, (TM)tumor suppressor gene PTEN, (PTEN)tumor suppressor protein 53, (p53)vascular smooth muscle cells, (VSMC)β-Arrestin

Identifiers

PMID31921393
PMCPMC6944711
OpenAlexW2969963508

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.