Evidence map›Paper›PMID 31921709›Full record

ReviewFrontiers in cellular and infection microbiology2019

Redox Balance Keepers and Possible Cell Functions Managed by Redox Homeostasis in

Andrea C Mesías, Nisha J Garg, M Paola Zago

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cellular and infection microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 46 citations in OpenAlex.

  1. Fluorination of amino-quinones enhances anti-RSC medicinal chemistry · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. LC-MS Evaluation of the Redox Trypanothione Balance inAntioxidants (Basel, Switzerland) · 2025
    Article
  6. Article
  7. Article
  8. Targeting Trypanothione Metabolism in Trypanosomatids.Molecules (Basel, Switzerland) · 2024
    Review
  9. Review
  10. A Review on the Immunological Response againstPathogens (Basel, Switzerland) · 2023
    Review
  11. Virulence · 2022
    Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Metabolomic Reprogramming of C57BL/6-Macrophages during Early Infection withInternational journal of molecular sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Andrea C MesíasInstituto de Patología Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) - Universidad Nacional de Salta, Salta, Argentina.
Nisha J GargDepartment of Microbiology and Immunology, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, United States.
M Paola ZagoInstituto de Patología Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) - Universidad Nacional de Salta, Salta, Argentina.
Consejo Nacional de Investigaciones Científicas y Técnicas · ARNational University of Salta · ARThe University of Texas Medical Branch at Galveston · US

Funding

Oxidative Response Networks in Chagasic CardiomyopathyR01AI136031 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Nisha Jain Garg · 2017 to 2026
$3.6M
Pathogenesis of Oxidative Stress in Chagasic MyocarditisR01AI054578 · NIAID · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI GARG, NISHA JAIN · 2005 to 2016
$3.3M
NIAID NIH HHS R01 AI054578NIAID NIH HHS R01 AI136031
6 · The paper itself

Abstract

The toxicity of oxygen and nitrogen reactive species appears to be merely the tip of the iceberg in the world of redox homeostasis. Now, oxidative stress can be seen as a two-sided process; at high concentrations, it causes damage to biomolecules, and thus, trypanosomes have evolved a strong antioxidant defense system to cope with these stressors. At low concentrations, oxidants are essential for cell signaling, and in fact, the oxidants/antioxidants balance may be able to trigger different cell fates. In this comprehensive review, we discuss the current knowledge of the oxidant environment experienced by

Indexed as

AnimalsAntioxidantsAntiparasitic AgentsChagas DiseaseGlutathioneHomeostasisHumansInsect VectorsNitrosative StressOxidantsOxidation-ReductionOxidative StressReactive Oxygen SpeciesSignal TransductionSpermidineTrypanosoma cruziAntioxidantsAntiparasitic AgentsGlutathioneOxidantsReactive Oxygen SpeciesSpermidinetrypanothioneantioxidant networkredox-dependent mechanismsregulationstage-specific oxidantsTrypanosoma cruzi

Identifiers

PMID31921709
PMCPMC6932984
OpenAlexW2995951143

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.