Evidence map›Paper›PMID 31926002›Full record

ReviewJournal of biochemistry2020

Regulation of growth in Drosophila melanogaster: the roles of mitochondrial metabolism.

Howard T Jacobs, Jack George, Esko Kemppainen

Open access · hybridAbstract readReview
In one paragraph

Review in Journal of biochemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Morphological innovation without gene co-option: thebioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Energetic Demands Regulate Sleep-Wake Rhythm Circuit Development.bioRxiv : the preprint server for biology · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. AmicroPublication biology · 2023
    Article
  11. Article
  12. Infection ofFrontiers in physiology · 2021
    Article
  13. International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Howard T JacobsFaculty of Medicine and Health Technology, FI-33014 Tampere University, Finland.
Jack GeorgeFaculty of Medicine and Health Technology, FI-33014 Tampere University, Finland.
Esko KemppainenFaculty of Medicine and Health Technology, FI-33014 Tampere University, Finland.
Tampere University · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondrial functions are often considered purely from the standpoint of catabolism, but in growing cells they are mainly dedicated to anabolic processes, and can have a profound impact on the rate of growth. The Drosophila larva, which increases in body mass ∼200-fold over the course of ∼3 days at 25°C, provides an excellent model to study the underlying regulatory machinery that connects mitochondrial metabolic capacity to growth. In this review, we will focus on several key aspects of this machinery: nutrient sensing, endocrine control of feeding and nutrient mobilization, metabolic signalling, protein synthesis regulation and pathways of steroid biosynthesis and activity. In all these aspects, mitochondria appear to play a crucial role.

Indexed as

AnimalsDrosophila melanogasterDrosophila ProteinsEcdysoneInhibitor of Apoptosis ProteinsLarvaMitochondriaNutrientsPositive Transcriptional Elongation Factor BProtein BiosynthesisWnt Signaling PathwayDIAP2 protein, DrosophilaDrosophila ProteinsEcdysoneInhibitor of Apoptosis ProteinsNutrientspgc protein, DrosophilaPositive Transcriptional Elongation Factor Becdysoneinsulin signallingPGC-1proteostasispyruvate

Identifiers

PMID31926002
PMCPMC7048069
OpenAlexW2999548903

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.