Evidence map›Paper›PMID 31927474›Full record

ArticleMedical image analysis2020

Multi-modal latent space inducing ensemble SVM classifier for early dementia diagnosis with neuroimaging data.

Tao Zhou, Kim-Han Thung, Mingxia Liu, Feng Shi, Changqing Zhang, Dinggang Shen

Open access · greenAbstract read
In one paragraph

Article in Medical image analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 104 citations in OpenAlex.

  1. Pooled it
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  13. Hybrid Multimodality Fusion with Cross-Domain Knowledge Transfer to Forecast Progression Trajectories in Cognitive Decline.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2023
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  15. Supervised Phenotype Discovery From Multimodal Brain Imaging.IEEE transactions on medical imaging · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 4 countries.

Tao ZhouDepartment of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, NC 27599, USA; Inception Institute of Artificial Intelligence, Abu Dhabi 51133, United Arab Emirates. Electronic address: taozhou.dreams@gmail.com.
Kim-Han ThungDepartment of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, NC 27599, USA. Electronic address: henrythung@gmail.com.
Mingxia LiuDepartment of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, NC 27599, USA. Electronic address: mxliu@med.unc.edu.
Feng ShiUnited Imaging Intelligence, Shanghai, China. Electronic address: feng.shi@united-imaging.com.
Changqing ZhangSchool of Computer Science and Technology, Tianjin University, Tianjin 300072, China. Electronic address: zhangchangqing@tju.edu.cn.
Dinggang ShenDepartment of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, NC 27599, USA; Department of Brain and Cognitive Engineering, Korea University, Seoul 02841, Republic of Korea. Electronic address: dgshen@med.unc.edu.
University of North Carolina at Chapel Hill · USTianjin University of Technology · CNUnited Imaging Healthcare (China) · CN

Funding

Quantifying Brain Abnormality by Multimodality Neuroimage Analysis,R01AG041721 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIU, MINGXIA · 2012 to 2019
$3.0M
NIA NIH HHS R01 AG041721
6 · The paper itself

Abstract

Fusing multi-modality data is crucial for accurate identification of brain disorder as different modalities can provide complementary perspectives of complex neurodegenerative disease. However, there are at least four common issues associated with the existing fusion methods. First, many existing fusion methods simply concatenate features from each modality without considering the correlations among different modalities. Second, most existing methods often make prediction based on a single classifier, which might not be able to address the heterogeneity of the Alzheimer's disease (AD) progression. Third, many existing methods often employ feature selection (or reduction) and classifier training in two independent steps, without considering the fact that the two pipelined steps are highly related to each other. Forth, there are missing neuroimaging data for some of the participants (e.g., missing PET data), due to the participants' "no-show" or dropout. In this paper, to address the above issues, we propose an early AD diagnosis framework via novel multi-modality latent space inducing ensemble SVM classifier. Specifically, we first project the neuroimaging data from different modalities into a latent space, and then map the learned latent representations into the label space to learn multiple diversified classifiers. Finally, we obtain the more reliable classification results by using an ensemble strategy. More importantly, we present a Complete Multi-modality Latent Space (CMLS) learning model for complete multi-modality data and also an Incomplete Multi-modality Latent Space (IMLS) learning model for incomplete multi-modality data. Extensive experiments using the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset have demonstrated that our proposed models outperform other state-of-the-art methods.

Indexed as

AgedAlzheimer DiseaseDatasets as TopicEarly DiagnosisFemaleHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMaleNeuroimagingPattern Recognition, AutomatedPositron-Emission TomographyAlzheimer’s disease (AD)Latent spaceMissing modalityMulti-modality dataMultiple diversified classifiers

Identifiers

PMID31927474
PMCPMC8260095
OpenAlexW2998710796

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.