Evidence map›Paper›PMID 31931977›Full record

Trial reportSurgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery2019

Adjustable gastric band surgery or medical management in patients with type 2 diabetes and obesity: three-year results of a randomized trial.

Donald C Simonson, Ashley Vernon, Kathleen Foster, Florencia Halperin, Mary Elizabeth Patti, Allison B Goldfine

Registry-linked trialAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01073020 (Surgery or Lifestyle With Intensive Medical Management in the Treatment of Type 2 Diabetes), which is not on this map. Cited by 19 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01073020 nacompletednot on this map

Surgery or Lifestyle With Intensive Medical Management in the Treatment of Type 2 Diabetes (SLIMM-T2D)

TypeinterventionalSponsorJoslin Diabetes CenterRan2010 to 2016Enrolled88ConditionsType 2 Diabetes Mellitus, ObesityArmsAllergan Adjustable Gastric Band Surgery, Intensive Medical Diabetes & Weight Management (Why WAIT) - Band Group, Roux-en-Y Gastric Bypass (RYGB) Surgery, Intensive Medical Diabetes & Weight Management (Why WAIT) - Bypass Group
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Guideline
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Oxidative Stress Responses in Obese Individuals Undergoing Bariatric Surgery: Impact on Carcinogenesis.Pathophysiology : the official journal of the International Society for Pathophysiology · 2024
    Review
  14. Article
  15. Article
  16. Article
  17. Observational
  18. Postbariatric hypoglycemia: symptom patterns and associated risk factors in the Longitudinal Assessment of Bariatric Surgery study.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2021
    Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Donald C SimonsonDivision of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address: dsimonso@hsph.harvard.edu.
Ashley VernonCenter for Metabolic and Bariatric Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Kathleen FosterResearch Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts.
Florencia HalperinDivision of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Mary Elizabeth PattiResearch Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts.
Allison B GoldfineDivision of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts.

Funding

Comparative Effectiveness of Medical Therapy vs. Bariatric Surgery for Obese T2DMRC1DK086918 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI GOLDFINE, ALLISON B, LAUTZ, DAVID BRADLEY · 2009 to 2010
$1.0M
Durability and Mechanisms of Bariatric Surgery vs Medical Therapy in Obese T2DR56DK095451 · NIDDK · JOSLIN DIABETES CENTER · PI GOLDFINE, ALLISON B, LAUTZ, DAVID BRADLEY · 2012 to 2013
$277k
NIDDK NIH HHS R56 DK095451NIDDK NIH HHS RC1 DK086918
6 · The paper itself

Abstract

backgroundFew randomized trials have compared surgical versus lifestyle and pharmacologic approaches for type 2 diabetes (T2D) patients with mild to moderate obesity.

objectivesThis study examined resolution of hyperglycemia (A1C <6.5% and fasting glucose <126 mg/dL) 3 years after randomization to either a laparoscopic adjustable gastric band (LAGB) or 1-year diabetes and weight management (DWM) program.

settingUniversity medical center, United States.

methodsForty T2D patients (mean ± SD: age, 51.3 ±10.0 yr; weight 109.5 ± 15.0 kg; body mass index [BMI] 36.5 ± 3.7 kg/m

resultsAt 3 years, 13% of 16 patients in LAGB and 5% of 17 patients in DWM achieved resolution of hyperglycemia (P = .601), with a modestly greater reduction in antidiabetic medications in the surgical group (P = .054). Reductions from baseline in A1C were sustained at 3 years in LAGB (-.82% [95% CI: -1.62 to -.01], P = .046) compared with DWM (+.23% [95% CI: -.57 to 1.03], P = .567). The surgical group had greater weight loss (-12.0 kg [95% CI: -15.9 to -8.1] versus -4.8 [95% CI: -8.6 to -.9], P = .010). HDL-cholesterol increased more after surgery (P = .003), but changes in triglycerides, LDL-cholesterol, and blood pressure did not differ between treatments. Diabetes- and obesity-specific quality of life improved comparably with both therapies.

conclusionsAchievement of American Diabetes Association targets for glucose, lipids, and blood pressure was similar with both treatment strategies. LAGB leads to greater sustained weight loss and higher HDL cholesterol compared with a DWM program. These findings may help guide patients with T2D and obesity when exploring options for diabetes and weight management.

Indexed as

Blood GlucoseDiabetes Mellitus, Type 2FemaleGastroplastyHumansHypoglycemic AgentsLaparoscopyLife StyleMaleMiddle AgedObesity, MorbidQuality of LifeWeight LossBlood GlucoseHypoglycemic AgentsBariatric surgeryLaparoscopic adjustable gastric bandObesityPatient-reported outcomestype 2 diabetesWeight management

Identifiers

PMID31931977
PMCPMC12677838

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.