ArticleInternational journal of clinical and experimental pathology2019
A panel of biomarkers for skin squamous cell carcinoma: various functional entities and differential responses to resveratrol.
Article in International journal of clinical and experimental pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- Evaluation of serum Cytokeratin 5 and p63 as non-invasive biomarkers for the diagnosis and staging of cervical cancer: a case-control study.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- Biomarkers in Cutaneous Keratinocyte Carcinomas.Dermatology and therapy · 2024Review
- Ex Vivo Analysis of Cell Differentiation, Oxidative Stress, Inflammation, and DNA Damage on Cutaneous Field Cancerization.International journal of molecular sciences · 2024Article
- Advancing Cancer Research: Current Knowledge on Cutaneous Neoplasia.International journal of molecular sciences · 2023Review
- Molecular Alterations in Cutaneous Squamous Cell Carcinoma in Immunocompetent and Immunosuppressed Hosts-A Systematic Review.Cancers · 2023Review
- Proteasome Subunit Alpha Type-7 Expression Suppresses Cutaneous Squamous Cell Carcinoma Progression by Inhibiting Cancer-associated Cytokines.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In contrast to the highly malignant melanoma, skin squamous cell carcinoma (SCC) usually presents with lower morbidity. However, its incidence has been alarmingly rising worldwide and is a public health burden, let alone the current SCC cancer classification scheme is inadequate. Due to its features of progressing along different pathologic stages, early detection of precancerous lesions with accurate molecular markers would be desirable for cancer prevention and treatment. In the present study, using immunohistochemical staining of 85 clinical samples, we profiled the expression of a panel of ten proteins from five functional divisions implicated in SCC development, i.e. cytokeratins, intercellular molecules, chaperone proteins, transcription factors, and mitochondrial redox enzymes. The differential alterations of the proteins in SCC cell lines SCL12 and COLO16, upon resveratrol therapy, were also examined by immunocytochemistry (ICC). Our data reveal that, while all these proteins show significant correlation with cancer initiation and/or progression, a comprehensive panel encompassing a range of biologic functions, instead of a single marker, will provide prognostic value in SCC diagnosis and management. Additionally, the strong correlation among the proteins with cancer stages implies their distinct roles in SCC pathogenesis and contributions to the therapeutic effects of resveratrol, which is demonstrated in the resveratrol-sensitive COLO16 cells, but not in the resveratrol-resistant SCL12 cells.
Indexed as
Identifiers
31933951PMC6947080W3003744747What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.