ArticleGlobal spine journal2020
Minimizing Blood Loss in Spine Surgery.
Article in Global spine journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 56 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Local Subfascial and Intramuscular Tranexamic Acid Administration in Pediatric Patient Undergoing Scoliosis Surgery, Double Blind Randomized Control Trial
Effect of Topical Tranexamic Acid on Postoperative Drainage in Minimally Invasive Transforaminal Lumbar Interbody Fusion (MI-TLIF): A Randomized Controlled Trial
Who cites it
56 citing papers in PubMed, 4 syntheses or guidelines pooled it, 112 citations in OpenAlex.
- Intraoperative cell salvage utilization for blood conservation during pediatric and adult spinal surgery: a state-of-the-art systematic review.Spine deformity · 2025Pooled it
- Effect of tranexamic acid in spine surgeries: a systematic review and network meta-analysis.Frontiers in surgery · 2025Pooled it
- Topical tranexamic acid (TXA) is non-inferior to intravenous TXA in adult spine surgery: a meta-analysis.Neurosurgical review · 2024Pooled it
- A systematic review of anterior lumbar interbody fusion (ALIF) versus posterior lumbar interbody fusion (PLIF), transforaminal lumbar interbody fusion (TLIF), posterolateral lumbar fusion (PLF).European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2023Pooled it
- Achieving Correction and Mitigating Complications in Adult Spinal Deformity through an Anterior-Posterior Combined Approach.Yonsei medical journal · 2026Article
- Cervical scoliosis surgery: understanding neurological complications and defining prevention strategies. A biomechanical study and narrative review.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Review
- No Difference Between Blood Preserving Strategies During Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis.Journal of the Pediatric Orthopaedic Society of North America · 2026Article
- Efficacy of Preoperative Oral Clonidine in Spine Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of clinical medicine · 2026Review
- Tranexamic Acid Versus no Tranexamic Acid in Spinal Tumor and Metastasis Surgery-Meta-Analysis.Global spine journal · 2026Review
- Elixhauser Comorbidity Index to Predict Perioperative Bleeding and Adverse Spine Surgery Outcomes.Journal of clinical medicine · 2026Article
- Determinants of 28-day perioperative mortality and postoperative length of hospital stay among geriatric patients: a two-center prospective follow-up study in Ethiopia.BMC geriatrics · 2026Article
- Is surgery for multiple myeloma-related spinal involvement associated with higher blood loss compared to spinal metastases?European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Spinous Process-Splitting Laminectomy Versus Conventional Laminectomy: A Short-Term Outcome Study.Cureus · 2026Article
- Tranexamic acid in spinal surgery: a stratified protocol from the surgeon's point of view.Brain & spine · 2026Article
- Intraoperative Cell Salvage in Spine Surgery: A Meta-Analysis of Reduced Allogeneic Transfusion with Implications for Orthopedic and Sports Practice.Orthopedic reviews · 2026Article
- Safety and efficacy of flowable microfibrillar collagen hemostat in an ovine model of lumbar laminectomy and open durotomy compared with the gelatin-thrombin hemostatic matrix and control.Frontiers in surgery · 2026Article
- BLEED-LESS: a scoping review on blood loss elimination in endoscopic decompression-lessons and literature on endoscopic spine surgery.Journal of spine surgery (Hong Kong) · 2025Review
- Beyond the Scalpel: EGFR Mutation Predicts Intraoperative Blood Loss and Transfusion Needs During Lung Cancer-derived Spinal Metastasis Surgery.Annals of surgical oncology · 2025Article
- Morbidity and Mortality of Pediatric Spinal Deformity Surgery Using the Japanese Orthopedic Association National Registry/Japanese Society for Spine Surgery and Related Research Database (JOANR/JSSR-DB).Spine surgery and related research · 2025Article
- Ultrasonic osteotome versus high-speed burr in channel-assisted cervical key hole technology: a clinical retrospective study.Journal of orthopaedic surgery and research · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
designBroad narrative review.
objectiveTo review and summarize the current literature on guidelines, outcomes, techniques and indications surrounding multiple modalities of minimizing blood loss in spine surgery.
methodsA thorough review of peer-reviewed literature was performed on the guidelines, outcomes, techniques, and indications for multiple modalities of minimizing blood loss in spine surgery.
resultsThere is a large body of literature that provides a consensus on guidelines regarding the appropriate timing of discontinuation of anticoagulation, aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), and herbal supplements prior to surgery. Additionally, there is a more heterogenous discussion the utility of preoperative autologous blood donation facilitated by erythropoietin and iron supplementation for healthy patients slated for procedures with high anticipated blood loss and for whom allogeneic transfusion is likely. Intraoperative maneuvers available to minimize blood loss include positioning and maintaining normothermia. Tranexamic acid (TXA), bipolar sealer electrocautery, and topical hemostatic agents, and hypotensive anesthesia (mean arterial pressure (MAP) <65 mm Hg) should be strongly considered in cases with larger exposures and higher anticipated blood loss. There is strong level 1 evidence for the use of TXA in spine surgery as it reduces the overall blood loss and transfusion requirements.
conclusionAs the volume and complexity of spinal procedures rise, intraoperative blood loss management has become a pivotal topic of research within the field. There are many tools for minimizing blood loss in patients undergoing spine surgery. The current literature supports combining techniques to use a cost- effective multimodal approach to minimize blood loss in the perioperative period.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.