ArticleInternational journal of clinical and experimental pathology2018
Expression of hydrogen sulfide synthases and Hh signaling pathway components correlate with the clinicopathological characteristics of papillary thyroid cancer patients.
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Significance of GSH and HRedox report : communications in free radical research · 2026Review
- Role of 3-mercaptopyruvate sulfurtransferase in cancer: Molecular mechanisms and therapeutic perspectives.Translational oncology · 2025Review
- Role of Hydrogen Sulfide in Oncological and Non-Oncological Disorders and Its Regulation by Non-Coding RNAs: A Comprehensive Review.Non-coding RNA · 2024Review
- Recent advances in the role of endogenous hydrogen sulphide in cancer cells.Cell proliferation · 2023Review
- The Role of Hydrogen Sulfide in the Development and Progression of Lung Cancer.Molecules (Basel, Switzerland) · 2022Review
- Gasotransmitters in the tumor microenvironment: Impacts on cancer chemotherapy (Review).Molecular medicine reports · 2022Review
- Emerging roles of cystathionine β-synthase in various forms of cancer.Redox biology · 2022Review
- Hydrogen Sulfide Biology and Its Role in Cancer.Molecules (Basel, Switzerland) · 2022Review
- Molecular Functions of Hydrogen Sulfide in Cancer.Pathophysiology : the official journal of the International Society for Pathophysiology · 2021Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine whether the expression levels of endogenous H
methodsA retrospective analysis was conducted of clinicopathological data obtained from 176 patients diagnosed with PTC, and immunohistochemical methods were used to detect the expression levels of endogenous H
resultsWe found that CSE was overexpressed in PTC tissues, while CBS and MPST were only slightly expressed in PTC tissues at levels similar to those in adjacent normal tissues. The levels of CSE expression were positively correlated with tumor size, extrathyroidal extension (ETE), and lymph node metastasis (LNM), but were not correlated with patient gender, age, or TNM stage. SHH, PTCH, and SMO Hh signaling pathway components were widely expressed in PTC tissues, and their expression correlated with larger tumor size, ETE, and LNM, but not with patient gender, age, or TNM stage, suggesting that activation of the Hh signaling pathway is involved in thyroid tumor progression.
conclusionsThese data suggest that a high level of CSE expression accompanied by Hh signaling pathway activation is involved in the pathogenesis and progression of PTC.
Indexed as
Identifiers
31938289PMC6958160W3026229209What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.