Evidence map›Paper›PMID 31948489›Full record

SynthesisSystematic reviews2020

Psychotropic medication non-adherence and its associated factors among patients with major psychiatric disorders: a systematic review and meta-analysis.

Agumasie Semahegn, Kwasi Torpey, Adom Manu, Nega Assefa, Gezahegn Tesfaye, Augustine Ankomah

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Systematic reviews, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07165821 (Effects of an Interpersonal Communication Skills Training Program on Medication Adherence of Schizophrenic Patients), which is not on this map. Cited by 256 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
256citing papers in PubMed, 14 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07165821 nacompletednot on this mapstarted 2024, after this paper: background citation

Effects of an Interpersonal Communication Skills Training Program on Medication Adherence of Schizophrenic Patients

TypeinterventionalSponsorSuranaree University of TechnologyRan2024 to 2024Enrolled40ConditionsSchizophrenia, Psychosis, Remission, Non-Adherence, MedicationArmsInterpersonal Communication Skills Training Program, Usual care
3 · Its place in the literature

Who cites it

256 citing papers in PubMed, 14 syntheses or guidelines pooled it.

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196 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Agumasie SemahegnDepartment of Population, Family and Reproductive Health, School of Public Health, College of Health Sciences, University of Ghana, Accra, Ghana. agucell@yahoo.com.ORCID 0000-0001-6625-8184
Kwasi TorpeyDepartment of Population, Family and Reproductive Health, School of Public Health, College of Health Sciences, University of Ghana, Accra, Ghana.
Adom ManuDepartment of Population, Family and Reproductive Health, School of Public Health, College of Health Sciences, University of Ghana, Accra, Ghana.
Nega AssefaCollege of Health and Medical Sciences, Haramaya University, Po Box 235, Harar, Ethiopia.
Gezahegn TesfayeCollege of Health and Medical Sciences, Haramaya University, Po Box 235, Harar, Ethiopia.
Augustine AnkomahPopulation Council/Ghana, Yiyiwa Drive, Accra, Ghana.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMajor psychiatric disorders are growing public health concern that attributed 14% of the global burden of diseases. The management of major psychiatric disorders is challenging mainly due to medication non-adherence. However, there is a paucity of summarized evidence on the prevalence of psychotropic medication non-adherence and associated factors. Therefore, we aimed to summarize existing primary studies' finding to determine the pooled prevalence and factors associated with psychotropic medication non-adherence.

methodsA total of 4504 studies written in English until December 31, 2017, were searched from the main databases (n = 3125) (PubMed (MEDLINE), Embase, CINAHL, PsycINFO, and Web of Science) and other relevant sources (mainly from Google Scholar, n = 1379). Study selection, screening, and data extraction were carried out independently by two authors. Observational studies that had been conducted among adult patients (18 years and older) with major psychiatric disorders were eligible for the selection process. Critical appraisal of the included studies was carried out using the Newcastle Ottawa Scale. Systematic synthesis of the studies was carried out to summarize factors associated with psychotropic medication non-adherence. Meta-analysis was carried using Stata 14. Random effects model was used to compute the pooled prevalence, and sub-group analysis at 95% confidence interval.

resultsForty-six studies were included in the systematic review. Of these, 35 studies (schizophrenia (n = 9), depressive (n = 16), and bipolar (n = 10) disorders) were included in the meta-analysis. Overall, 49% of major psychiatric disorder patients were non-adherent to their psychotropic medication. Of these, psychotropic medication non-adherence for schizophrenia, major depressive disorders, and bipolar disorders were 56%, 50%, and 44%, respectively. Individual patient's behaviors, lack of social support, clinical or treatment and illness-related, and health system factors influenced psychotropic medication non-adherence.

conclusionPsychotropic medication non-adherence was high. It was influenced by various factors operating at different levels. Therefore, comprehensive intervention strategies should be designed to address factors associated with psychotropic medication non-adherence. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42017067436.

Indexed as

Drug MonitoringBehaviorBipolar DisorderMajor Depressive DisorderPsychotropic DrugsSchizophreniaSocial SupportPsychotropic DrugsMedication non-adherenceMeta-analysisPsychiatric disordersSystematic review

Identifiers

PMID31948489
PMCPMC6966860

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.