ArticleInternational journal of clinical and experimental pathology2018
Predictive effect of exhaled NO and VEGF expression levels on the severity of bronchial asthma and airway inflammation.
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
- Review
- Plasticity of Naturally Occurring Regulatory T Cells in Allergic Airway Disease Is Modulated by the Transcriptional Activity ofInternational journal of molecular sciences · 2021Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the relationship between exhaled NO and vascular endothelial growth factor (VEGF) expression in bronchial asthma patients with asthma severity and airway inflammation.
methodsFrom January 2015 to December 2017, 260 patients with bronchial asthma diagnosed in our hospital were enrolled. The expression of VEGF in the induced sputum was measured by enzyme-linked immunosorbent assay (ELISA) in the control (n=260) and asthma groups (n=260) in the same period. The NO concentration was measured on the same day.
resultsIntercellular adhesion molecule-1 (ICAM-1), VEGF, tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels were significantly elevated in sputum of patients with acute asthma, and the concentration in exhaled NO of all patients was also significantly higher than the control group and the stable phase of asthma. The expression of ICAM-1, VEGF, TNF-α and IL-6 was significantly elevated in patients with severe asthma. There were significant differences in patients with mild to moderate asthma (P<0.05). Correlation analysis showed that VEGF, IL-6 and TNF-α were positively correlated with the degree of asthma (P<0.05), but negatively correlated with FEV1.0, FEV1.0/FVC% and PEF (P<0.05).
conclusionThe expression of VEGF in sputum in patients with bronchial asthma is closely related to the severity of asthma and airway inflammation.
Indexed as
Identifiers
31949622PMC6963026W3027392003What Socratic holds
Registered trials
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