Evidence map›Paper›PMID 31952804›Full record

ArticleBiophysical journal2020

Synaptotagmin-1 and Doc2b Exhibit Distinct Membrane-Remodeling Mechanisms.

Raya Sorkin, Margherita Marchetti, Emma Logtenberg, Melissa C Piontek, Emma Kerklingh, Guy Brand, Rashmi Voleti, Josep Rizo, Wouter H Roos, Alexander J Groffen and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Biophysical journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Generation of nanoscopic membrane curvature for membrane trafficking.Nature reviews. Molecular cell biology · 2023
    Review
  6. Article
  7. Review
  8. Membrane fusion studied by colloidal probes.European biophysics journal : EBJ · 2021
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Raya SorkinDepartment of Physics and Astronomy and LaserLab, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Department of Molecular Biophysics, Zernike Instituut, Rijksuniversiteit Groningen, Groningen, the Netherlands; Raymond & Beverly Sackler School of Chemistry, Tel Aviv University, Tel Aviv, Israel.
Margherita MarchettiDepartment of Physics and Astronomy and LaserLab, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Department of Molecular Biophysics, Zernike Instituut, Rijksuniversiteit Groningen, Groningen, the Netherlands.
Emma LogtenbergDepartment of Functional Genomics and Clinical Genetics, Vrije Universiteit and VU Medical Center Amsterdam, Amsterdam, the Netherlands.
Melissa C PiontekDepartment of Molecular Biophysics, Zernike Instituut, Rijksuniversiteit Groningen, Groningen, the Netherlands.
Emma KerklinghDepartment of Physics and Astronomy and LaserLab, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Guy BrandDepartment of Physics and Astronomy and LaserLab, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Rashmi VoletiDepartments of Biophysics, Biochemistry, and Pharmacology, UT Southwestern Medical Center, Dallas, Texas.
Josep RizoDepartments of Biophysics, Biochemistry, and Pharmacology, UT Southwestern Medical Center, Dallas, Texas.
Wouter H RoosDepartment of Molecular Biophysics, Zernike Instituut, Rijksuniversiteit Groningen, Groningen, the Netherlands.
Alexander J GroffenDepartment of Functional Genomics and Clinical Genetics, Vrije Universiteit and VU Medical Center Amsterdam, Amsterdam, the Netherlands.
Gijs J L WuiteDepartment of Physics and Astronomy and LaserLab, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. Electronic address: gwuite@nat.vu.nl.
Vrije Universiteit Amsterdam · NLUniversity of Groningen · NLSouthwestern Medical CenterSouthwestern Medical Center · US

Funding

Mechanisms of neurotransmitter release and its regulationR35NS097333 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI RIZOREY, JOSE · 2017 to 2024
$7.0M
NINDS NIH HHS R35 NS097333
6 · The paper itself

Abstract

Synaptotagmin-1 (Syt1) is a calcium sensor protein that is critical for neurotransmission and is therefore extensively studied. Here, we use pairs of optically trapped beads coated with SNARE-free synthetic membranes to investigate Syt1-induced membrane remodeling. This activity is compared with that of Doc2b, which contains a conserved C

Indexed as

CalciumCalcium-Binding ProteinsMembrane FusionNerve Tissue ProteinsSynaptotagmin IHumansProtein BindingSNARE ProteinsSynaptic TransmissionCalciumCalcium-Binding ProteinsDOC2B protein, humanNerve Tissue ProteinsSNARE ProteinsSynaptotagmin I

Identifiers

PMID31952804
PMCPMC7002981
OpenAlexW2997177874

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.