ArticleThe Journal of infectious diseases2020
Frailty Is Associated With Mortality and Incident Comorbidity Among Middle-Aged Human Immunodeficiency Virus (HIV)-Positive and HIV-Negative Participants.
Article in The Journal of infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01466582 (Comorbidity and Aging With HIV, the agehIV Cohort Study), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comorbidity and Aging With HIV, the agehIV Cohort Study
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Guideline
- Article
- Prevalence and clinical correlates of frailty among adults with HIV infection and unhealthy alcohol or drug use.AIDS (London, England) · 2026Article
- Article
- Systematic screening for age-related comorbidities: Health care optimization among persons with HIV in an outpatient setting.HIV medicine · 2026Article
- Exploring frailty in the context of HIV and aging in Kazakhstan: findings from a pilot cross-sectional study.BMC public health · 2026Article
- Modeled Health and Economic Burden of Frailty and Falls Among Adults With HIV.JAMA network open · 2026Article
- Inflammation in frailty, cognitive impairment, clinical events, and mortality among older adults with HIV in the ACTG HAILO cohort.AIDS (London, England) · 2025Observational
- The burden of mental health problems among elderly persons living with HIV in countries across sub-Saharan Africa: systematic review and meta-analysis protocol.Systematic reviews · 2025Article
- Approaches to optimally target frailty screening among people with HIV in clinical care: findings from the Centers for AIDS Research Network of Integrated Clinical Systems (CNICS).Journal of acquired immune deficiency syndromes (1999) · 2025Article
- Cardiometabolic disease among frailty phenotype clusters in adults aging with HIV.The Journal of frailty & aging · 2025Article
- Experiences, Challenges, and Needs of People Living with HIV in Hunan Province, China: A Qualitative Study.Journal of multidisciplinary healthcare · 2025Article
- HIV reservoir and premature aging: risk factors for aging-associated illnesses in adolescents and young adults with perinatally acquired HIV.PLoS pathogens · 2024Article
- Frailty assessment: An emerging concept in aged People Living with HIV (PLHIV).Journal of family medicine and primary care · 2023Article
- Impaired gut microbiota-mediated short-chain fatty acid production precedes morbidity and mortality in people with HIV.Cell reports · 2023Article
- Effects of frailty, geriatric syndromes, and comorbidity on mortality and quality of life in older adults with HIV.BMC geriatrics · 2023Article
- Loneliness and Frailty Among Middle-Aged and Aging Sexual Minority Men Living With or Without HIV: A Longitudinal Cross-Lagged Panel Analysis.Innovation in aging · 2023Article
- Frailty in older people living with HIV: current status and clinical management.BMC geriatrics · 2022Review
- Associations between drug and alcohol use, smoking, and frailty among people with HIV across the United States in the current era of antiretroviral treatment.Drug and alcohol dependence · 2022Article
- Multimorbidity networks associated with frailty among middle-aged and older people with HIV.AIDS (London, England) · 2021Article
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundFrailty is associated with mortality and morbidity in the general geriatric population, but less is known about its impact among the aging but generally younger population with human immunodeficiency virus (HIV).
methodsThe impact of frailty on all-cause mortality during 6 years of follow-up and incident comorbidity during 4 years of follow-up was assessed among 598 HIV-positive and 550 comparable HIV-negative participants aged ≥ 45 years of the AGEhIV Cohort Study. Frailty encompasses 5 domains; weight loss, low physical activity, exhaustion, decreased grip strength, and slow gait speed. Presence of ≥ 3 denotes frailty, 1-2 prefrailty, and 0 robust. Multivariable Cox and logistic regression models were used to assess the independent relationships of frailty with both outcomes, adjusting for HIV infection and traditional risk factors.
resultsAt baseline, 7.5% (n = 86) of participants were frail. During follow-up, 38 participants died. Mortality rate was significantly higher among frail participants: 25.7/1000 person-years of follow-up (PYFU) (95% confidence interval [CI], 14.2-46.4) compared with prefrail (7.2/1000 PYFU [95% CI, 4.7-11.2]) and robust (2.3/1000 PYFU [95% CI, 1.1-4.9]). In fully adjusted analyses, frailty remained strongly associated with death (hazard ratio, 4.6 [95% CI, 1.7-12.5]) and incident comorbidity (odds ratio, 1.9 [95% CI, 1.1-3.1]). No interactions were observed between frailty and HIV status in all analyses.
conclusionsFrailty is a strong predictor of both mortality and incident comorbidity independent from other risk factors. CLINICAL TRIALS REGISTRATION: NCT01466582.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.