Evidence map›Paper›PMID 31959871›Full record

SynthesisJournal of human genetics2020

Genome-wide meta-analysis associates GPSM1 with type 2 diabetes, a plausible gene involved in skeletal muscle function.

Qiuju Ding, Amelia Li Min Tan, E J Parra, Miguel Cruz, Xueling Sim, Yik-Ying Teo, Jirong Long, Habiba Alsafar, Enrico Petretto, E-Shyong Tai and 1 more

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Journal of human genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. The Effect ofPharmacogenomics and personalized medicine · 2022
    Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 6 countries.

Qiuju Ding *National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China, 210016.
Amelia Li Min Tan *Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
E J ParraDepartment of Anthropology, University of Toronto at Mississauga, 3359 Mississauga Road North, Mississauga, ON, L5L 1C6, Canada.
Miguel CruzUnidad de Investigacion Medica en Bioquimica, Hospital de Especialidades, Centro Medico 'Siglo XXI', IMSS, Mexico City, Mexico.
Xueling SimSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.ORCID http://orcid.org/0000-0002-1233-7642
Yik-Ying TeoSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Jirong LongDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
Habiba AlsafarCenter for Biotechnology, Khalifa University of Science & Technology, Abu Dhabi, United Arab Emirates.
Enrico PetrettoDuke-NUS Medical School, 8 College Road, Singapore, 169857, Singapore.ORCID http://orcid.org/0000-0003-2163-5921
E-Shyong TaiDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Huimei ChenNational Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China, 210016. chenhuimei@nju.edu.cn.
National University of Singapore · SGNanjing General Hospital of Nanjing Military Command · CNDuke-NUS Medical School · SGHospital de Especialidades · MXKhalifa University of Science and Technology · AEUniversity of Toronto · CAVanderbilt University · US

Funding

National Natural Science Foundation of China (National Science Foundation of China) 181570714National Natural Science Foundation of China (National Science Foundation of China) 8161113013
6 · The paper itself

Abstract

Genome-wide association studies (GWASs) have identified many genetic variations associated with type 2 diabetes mellitus (T2DM) in Asians, but understanding the functional genetic variants that influence traits is often a complex process. In this study, fine mapping and other analytical strategies were performed to investigate the effects of G protein signaling modulator 1 (GPSM1) on insulin resistance in skeletal muscle. A total of 128 single-nucleotide polymorphisms (SNPs) within GPSM1 were analysed in 21,897 T2DM cases and 32,710 healthy controls from seven GWASs. The SNP rs28539249 in intron 9 of GPSM1 showed a nominally significant association with T2DM in Asians (OR = 1.07, 95% CI = 1.04-1.10, P < 10

Indexed as

Diabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2Genetic Predisposition to DiseaseGuanine Nucleotide Dissociation InhibitorsPolymorphism, Single NucleotideAnimalsAsian PeopleGenome-Wide Association StudyHumansMiceMuscle, SkeletalGPSM1 protein, humanGpsm1 protein, mouseGuanine Nucleotide Dissociation Inhibitors

Identifiers

PMID31959871
OpenAlexW3000285473

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.