ReviewInternational journal of molecular sciences2020
Inactivity and Skeletal Muscle Metabolism: A Vicious Cycle in Old Age.
Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 1 synthesis or guideline pooled it, 103 citations in OpenAlex.
- Interplay between frailty and cardiometabolic disorders: from pathophysiology to clinical implications.Cardiovascular diabetology · 2025Pooled it
- Effects of Peanut Butter Supplementation on Older Adults' Physical Function: A 6-Month Randomised Controlled Trial.Journal of cachexia, sarcopenia and muscle · 2026Trial
- The effect of a family-centered empowerment model with traditional Chinese medicine health education on self-management in community-dwelling older adult hypertensive patients with a chance health locus of control.Frontiers in public health · 2026Trial
- High-intensity interval swimming improves cardiovascular endurance, while aquatic resistance training enhances muscular strength in older adults.Scientific reports · 2024Trial
- Evaluation of Measured Resting Metabolic Rate for Dietary Prescription in Ageing Adults with Overweight and Adiposity-Based Chronic Disease.Nutrients · 2021Trial
- A Biomimetic 3D Human Skeletal Muscle Microtissue for Modeling Biological and Functional Hallmarks of Aging.Small science · 2026Article
- CaMKIIγ/δ contributes to mitochondrial metabolic adaptation in skeletal muscle during endurance training.Molecular metabolism · 2026Article
- Metformin Partially Attenuates Simvastatin-Induced Myotoxic Responses in C2C12 Myotubes Through Metabolic Adaptation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Commentary on: Associations of accelerometer-measured light-intensity physical activity with mortality and incidence of cardiovascular disease and cancers: A prospective UK Biobank cohort analysis.Journal of sport and health science · 2026Article
- Role of mitochondrial dysfunction in muscle wasting in cancer cachexia: a narrative review.Journal of translational medicine · 2026Review
- The triad of collagen, vitamin C, and vitamin E in aging: emerging roles in mood and psychological health, neurotrophic support, cognitive function, endurance, and sarcopenia.Frontiers in nutrition · 2026Review
- Equation-derived SMI not generalizable for DXA-defined low muscle mass in Chinese adults: external validation study.Frontiers in nutrition · 2026Article
- Comparative effects of pea protein vs. dairy proteins (α-lactalbumin and casein) on aminoacidemia, exercise performance, gut microbiota, hormonal responses, neurocognitive function, mood, and metabolic-inflammatory responses in older adults.Frontiers in nutrition · 2026Review
- Article
- Polypharmacy and Dynapenia in Older Adults Undergoing Rehabilitation After Fracture or Elective Orthopedic Surgery.Medicina (Kaunas, Lithuania) · 2025Article
- Successful application of innovative hybrid anticoagulation in continuous renal replacement therapy for an ultra-elderly patient: a case report.BMC nephrology · 2025Article
- Association of Low Muscle Mass, Weak Grip Strength, and Neutrophil-to-Lymphocyte Ratio in Old Ages.Journal of bone metabolism · 2025Article
- Effects of Twelve Weeks of Square Stepping Exercises on Physical and Cognitive Function and Plasma Content of SMP30: A Randomised Control Trial.Geriatrics (Basel, Switzerland) · 2025Article
- Yoga Practice as a Potential Sarcopenia Prevention Strategy in Indonesian Older Adults: A Cross-Sectional Study.Open access journal of sports medicine · 2025Article
- A single bout of prior resistance exercise attenuates muscle atrophy and declines in myofibrillar protein synthesis during bed-rest in older men.The Journal of physiology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aging is an inevitable and gradually progressive process affecting all organs and systems. The musculoskeletal system makes no exception, elderly exhibit an increased risk of sarcopenia (low muscle mass),dynapenia (declining muscle strength), and subsequent disability. Whereas in recent years the subject of skeletal muscle metabolic decline in the elderly has been gathering interest amongst researchers, as well as medical professionals, there are many challenges yet to be solved in order to counteract the effects of aging on muscle function efficiently. Noteworthy, it has been shown that aging individuals exhibit a decline in skeletal muscle metabolism, a phenomenon which may be linked to a number of predisposing (risk) factors such as telomere attrition, epigenetic changes, mitochondrial dysfunction, sedentary behavior (leading to body composition alterations), age-related low-grade systemic inflammation (inflammaging), hormonal imbalance, as well as a hypoproteic diet (unable to counterbalance the repercussions of the age-related increase in skeletal muscle catabolism). The present review aims to discuss the relationship between old age and muscle wasting in an effort to highlight the modifications in skeletal muscle metabolism associated with aging and physical activity.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.