Evidence map›Paper›PMID 31965140›Full record

Trial reportThe American journal of clinical nutrition2020

Association of egg intake with blood lipids, cardiovascular disease, and mortality in 177,000 people in 50 countries.

Mahshid Dehghan, Andrew Mente, Sumathy Rangarajan, Viswanathan Mohan, Scott Lear, Sumathi Swaminathan, Andreas Wielgosz, Pamela Seron, Alvaro Avezum, Patricio Lopez-Jaramillo and 25 more

2 registry-linked trialsOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of clinical nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 47 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 6 pooled it
13.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00153101 phase4completednot on this map

ONTARGET ONgoing Telmisartan Alone and in Combination With Ramipril Global Endpoint Trial A Large, Simple Randomized Trial of an Angiotensin II Receptor Antagonist (Telmisartan) and an ACE-Inhibitor (Ramipril) in Patients at High Risk for Cardiovascular Events and TRANSCEND Telmisartan Randomized AssessmeNt Study in aCE iNtolerant Subjects With Cardiovascular Disease. A Parallel Study Comparing the Effects of Telmisartan With Placebo and Outcomes in Patients at High Risk for Cardiovascular Events and Intolerant to ACE-I.

TypeinterventionalSponsorBoehringer IngelheimRan2001Enrolled31,546ConditionsCardiovascular DiseasesArmsTelmisartan, Combination of Telmisartan and Ramipril, Ramipril
NCT03225586 recruitingnot on this map

Prospective Urban Rural Epidemiology Study

TypeobservationalSponsorPopulation Health Research InstituteRan2002 to 2030Enrolled200,000ConditionsCardiovascular Diseases, Risk Factor, Cardiovascular, Health Behavior, Environmental Exposure
3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 6 syntheses or guidelines pooled it, 99 citations in OpenAlex.

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  20. Dietary management of dyslipidemia.Indian heart journal · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

35 authors at 20 institutions in 21 countries.

Mahshid DehghanPopulation Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Andrew MentePopulation Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Sumathy RangarajanPopulation Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Viswanathan MohanDr. Mohan's Diabetes Specialities Centre, Gopalapuram, Chennai, India.
Scott LearFaculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.
Sumathi SwaminathanDivision of Nutrition, St John's Research Institute, Koramangala, Bangalore, India.
Andreas WielgoszDepartment of Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Pamela SeronFaculty of Medicine, University of La Frontera, Temuco, Chile.
Alvaro AvezumDante Pazzanese Institute of Cardiology, Sao Paulo, Brazil.
Patricio Lopez-JaramilloFOSCAL, Medical School, University of Santander, Bucaramanga, Colombia.
Ginette TurbideHeart and Lung Institute, Laval University, Quebec City, QC, Canada.
Jephat ChifambaUniversity of Zimbabwe College of Health Sciences, Harare, Zimbabwe.
Khalid F AlHabibDepartment of Cardiac Sciences, King Fahad Cardiac Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Noushin MohammadifardIsfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Andrzej SzubaDivision of Angiology, Wroclaw Medical University, Wroclaw, Poland.
Rasha KhatibInstitute for Community and Public Health, Birzeit University, Birzeit, Palestine.
Yuksel AltuntasClinic of Endocrinology and Metabolism Sisli, Istanbul Sisli Hamidiye Etfal Health Training and Research Hospital, Faculty of Medicine, University of Health Sciences, Istanbul, Turkey.
Xiaoyun LiuState Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences, Beijing, China.
Romaina IqbalDepartment of Community Health Sciences and Medicine, Aga Khan University, Karachi, Pakistan.
Annika RosengrenDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, and Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden.
Rita YusufSchool of Life Sciences, Independent University, Dhaka, Bangladesh.
Marius SmutsCentre of Excellence for Nutrition, North-West University, Potchefstroom, South Africa.
AfzalHussein YusufaliHatta Hospital, Dubai Medical University, Dubai Health Authority, Dubai, UAE.
Ning LiQingshan Lake Community Health Service Center, Nanchang City, China.
Rafael DiazClinical Studies Latin America, Rosario, Santa Fe, Argentina.
Khalid YusoffDepartment of Medicine, Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia.
Manmeet KaurPost Graduate Institute of Medical Education and Research, School of Public Health, Chandigarh, India.
Biju SomanHealth Action by People, Thiruvananthapuram, India.
Noorhassim IsmailDepartment of Community Health, University Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia.
Rajeev GuptaEternal Heart Care Centre & Research Institute, Jaipur, India.
Antonio DansDepartment of Medicine, University of the Philippines, Manila, Philippines.
Patrick SheridanPopulation Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Koon TeoPopulation Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Sonia S AnandPopulation Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Salim YusufPopulation Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Population Health Research Institute · CAChinese Academy of Medical Sciences & Peking Union Medical College · CNKing Saud University · SAAdvocate Health Care · USAga Khan University · PKDr. Mohan's Diabetes Specialities Centre · INDubai Health Authority · AEEstudios Clínicos Latinoamérica · AREternal Hospital · INIndependent University · BDInstituto Dante Pazzanese de Cardiologia · BRIsfahan University of Medical Sciences · IRNorth-West University · ZAPost Graduate Institute of Medical Education and Research · INSağlık Bilimleri Üniversitesi · TRSahlgrenska University Hospital · SESimon Fraser University · CASree Chitra Thirunal Institute for Medical Sciences and Technology · INSt. John's National Academy of Health Sciences · INUniversidad de La Frontera · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEggs are a rich source of essential nutrients, but they are also a source of dietary cholesterol. Therefore, some guidelines recommend limiting egg consumption. However, there is contradictory evidence on the impact of eggs on diseases, largely based on studies conducted in high-income countries.

objectivesOur aim was to assess the association of egg consumption with blood lipids, cardiovascular disease (CVD), and mortality in large global studies involving populations from low-, middle-, and high-income countries.

methodsWe studied 146,011 individuals from 21 countries in the Prospective Urban Rural Epidemiology (PURE) study. Egg consumption was recorded using country-specific validated FFQs. We also studied 31,544 patients with vascular disease in 2 multinational prospective studies: ONTARGET (Ongoing Telmisartan Alone and in Combination with Ramipril Global End Point Trial) and TRANSCEND (Telmisartan Randomized Assessment Study in ACEI Intolerant Subjects with Cardiovascular Disease). We calculated HRs using multivariable Cox frailty models with random intercepts to account for clustering by study center separately within each study.

resultsIn the PURE study, we recorded 14,700 composite events (8932 deaths and 8477 CVD events). In the PURE study, after excluding those with history of CVD, higher intake of egg (≥7 egg/wk compared with <1 egg/wk intake) was not significantly associated with blood lipids, composite outcome (HR: 0.96; 95% CI: 0.89, 1.04; P-trend = 0.74), total mortality (HR: 1.04; 95% CI: 0.94, 1.15; P-trend = 0.38), or major CVD (HR: 0.92; 95% CI: 0.83, 1.01; P-trend = 0.20). Similar results were observed in ONTARGET/TRANSCEND studies for composite outcome (HR 0.97; 95% CI: 0.76, 1.25; P-trend = 0.09), total mortality (HR: 0.88; 95% CI: 0.62, 1.24; P-trend = 0.55), and major CVD (HR: 0.97; 95% CI: 0.73, 1.29; P-trend = 0.12).

conclusionsIn 3 large international prospective studies including ∼177,000 individuals, 12,701 deaths, and 13,658 CVD events from 50 countries in 6 continents, we did not find significant associations between egg intake and blood lipids, mortality, or major CVD events. The ONTARGET and TRANSCEND trials were registered at clinicaltrials.gov as NCT00153101. The PURE trial was registered at clinicaltrials.gov as NCT03225586.

Indexed as

AdultAngiotensin-Converting Enzyme InhibitorsCardiovascular DiseasesEggsFemaleHumansLipidsMaleMiddle AgedProportional Hazards ModelsProspective StudiesRamiprilTelmisartanAngiotensin-Converting Enzyme InhibitorsLipidsRamiprilTelmisartanblood lipidscardiovascular diseasedietary cholesterolegg intakemortality

Identifiers

PMID31965140
PMCPMC7138651
OpenAlexW3001214052

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.