Evidence map›Paper›PMID 31977249›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2020

TASK-1 and TASK-3 channels modulate pressure overload-induced cardiac remodeling and dysfunction.

Wei Duan, Jonné Hicks, Michael A Makara, Olga Ilkayeva, Dennis M Abraham

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. KPharmaceuticals (Basel, Switzerland) · 2026
    Review
  3. Genetic Variants inInternational journal of molecular sciences · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Wei DuanDepartment of Medicine, Duke University Medical Center, Durham, North Carolina.
Jonné HicksDepartment of Medicine, Duke University Medical Center, Durham, North Carolina.
Michael A MakaraDOCS Global, Durham, North Carolina.
Olga IlkayevaDuke Molecular Physiology Institute, Duke University, Durham, North Carolina.
Dennis M AbrahamDepartment of Medicine, Duke University Medical Center, Durham, North Carolina.
Duke Medical Center · USDuke University · US

Funding

TREK-1 in fibroblast differentiation and cardiac fibrosis developmentK08HL125905 · NHLBI · DUKE UNIVERSITY · PI ABRAHAM, DENNIS · 2015 to 2019
$746k
NHLBI NIH HHS K08 HL125905
6 · The paper itself

Abstract

Tandem pore domain acid-sensitive K

Indexed as

AnimalsCardiomegalyCardiomyopathiesHumansMiceMice, KnockoutMyocardiumMyocytes, CardiacNerve Tissue ProteinsPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPhosphorylationPotassium ChannelsPotassium Channels, Tandem Pore DomainProto-Oncogene Proteins c-aktVentricular RemodelingNerve Tissue ProteinsPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPotassium ChannelsPotassium Channels, Tandem Pore Domainpotassium channel subfamily K member 3Ppargc1a protein, mouseProto-Oncogene Proteins c-aktTASK3 protein, mousecardiac agingcardiac functioncardiac hypertrophyknockout mouse modelTASK channels

Identifiers

PMID31977249
PMCPMC7099448
OpenAlexW3002056531

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.