Evidence mapPaperPMID 31979006Full record

ArticleInternational journal of molecular sciences2020

Flexible Data Trimming Improves Performance of Global Machine Learning Methods in Omics-Based Personalized Oncology.

Victor Tkachev, Maxim Sorokin, Constantin Borisov, Andrew Garazha, Anton Buzdin, Nicolas Borisov

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Recent Trends in Cancer Genomics and Bioinformatics Tools Development.International journal of molecular sciences · 2021
    Article
  8. Article
  9. Article
  10. Article
  11. Bioinformatics Methods in Medical Genetics and Genomics.International journal of molecular sciences · 2020
    Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Victor TkachevOmicsWayCorp, Walnut, CA 91788, USA.
Maxim SorokinOmicsWayCorp, Walnut, CA 91788, USA.
Constantin BorisovNational Research University-Higher School of Economics, 101000 Moscow, Russia.
Andrew GarazhaOmicsWayCorp, Walnut, CA 91788, USA.
Anton BuzdinOmicsWayCorp, Walnut, CA 91788, USA.
Nicolas BorisovOmicsWayCorp, Walnut, CA 91788, USA.

Funding

Russian Foundation for Basic Research 19-29-01108
6 · The paper itself

Abstract

(1) Background: Machine learning (ML) methods are rarely used for an omics-based prescription of cancer drugs, due to shortage of case histories with clinical outcome supplemented by high-throughput molecular data. This causes overtraining and high vulnerability of most ML methods. Recently, we proposed a hybrid global-local approach to ML termed floating window projective separator (FloWPS) that avoids extrapolation in the feature space. Its core property is data trimming, i.e., sample-specific removal of irrelevant features. (2) Methods: Here, we applied FloWPS to seven popular ML methods, including linear SVM,

Indexed as

Antineoplastic AgentsHigh-Throughput Screening AssaysHumansMachine LearningMedical OncologyNeoplasmsPrecision MedicineAntineoplastic Agentsbioinformaticschemotherapymachine learningomics profilingoncologypersonalized medicine

Identifiers

PMID31979006
PMCPMC7037338

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.