ReviewInternational journal of molecular sciences2020
Omega-3 Versus Omega-6 Polyunsaturated Fatty Acids in the Prevention and Treatment of Inflammatory Skin Diseases.
Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06995586 (The Synergistic Action of Vitamins and Dietary Supplements in Patients With Coronary Artery Bypass Grafting for Improving the Quality of Healthcare Delivery.), which is not on this map. Cited by 147 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Synergistic Action of Vitamins and Dietary Supplements in Patients With Coronary Artery Bypass Grafting for Improving the Quality of Healthcare Delivery.
Who cites it
147 citing papers in PubMed, 3 syntheses or guidelines pooled it, 367 citations in OpenAlex.
- Genetic evidence of the causal relationship between genetically predicted nutrients and psoriatic arthritis.Clinical rheumatology · 2026Pooled it
- Therapeutic Benefits of Topical Omega-3 Polyunsaturated Fatty Acids in Skin Diseases and Cosmetics: An Updated Systematic Review.Journal of cosmetic dermatology · 2025Pooled it
- Exploring clinical and genetic evidence in association between unsaturated fatty acids and acne.European journal of nutrition · 2025Pooled it
- Trial
- Krill oil supplementation improves transepidermal water loss, hydration and elasticity of the skin in healthy adults: Results from two randomized, double-blind, placebo-controlled, dose-finding pilot studies.Journal of cosmetic dermatology · 2024Trial
- Effect of Omega-3 Polyunsaturated Fatty Acid Supplementation on Clinical Outcome of Atopic Dermatitis in Children.Nutrients · 2024Trial
- Evaluation of a multi-component dietary supplement combined with probiotic and omega-3 in individuals with self-reported symptoms of brain fog: an 8-week exploratory study.Future science OA · 2026Article
- Dates, Polyunsaturated Fatty Acids, Dietary Fiber, and Probiotics as Potential Complementary Modulators of Gut Microbiota and Oxidative Stress: An Integrative Review.Antioxidants (Basel, Switzerland) · 2026Review
- Ultra-Processed Diets and Pediatric Acne: Insulin-mTOR Activation and Its Potential Role in Cutaneous Inflammation.International journal of molecular sciences · 2026Review
- Night-Time Biomass and Compositional Dynamics inBiotech (Basel (Switzerland)) · 2026Article
- Lipid Metabolism, Body Composition, and Diet in Acne Vulgaris: A Narrative Review.Metabolites · 2026Review
- Integrative Dermatology for Longevity: The Synergy of Topical and Internal Approaches.Dermatology and therapy · 2026Review
- Evaluation of Antioxidant Activity and Physicochemical Characterization of Walnut (International journal of molecular sciences · 2026Article
- Dietary supplementation with the hexane fraction of Ulva fasciata extract improves growth performance, immune responses, and antioxidant status in Nile tilapia (Oreochromis niloticus).Fish physiology and biochemistry · 2026Article
- Anti-Inflammatory Activities of Baobab Fruit Extracts in TNF-Pharmaceuticals (Basel, Switzerland) · 2026Article
- Assessing the Physiology and Biochemistry of Freshwater Microalgae for Biotechnological Applications.Applied biochemistry and biotechnology · 2026Article
- Maternal nutrition practices and its implications for child growth and development in Jimma Town a community based cross sectional study.Scientific reports · 2026Article
- Lipid metabolism in homeostasis and disease.Signal transduction and targeted therapy · 2026Review
- Incidence Rate of Otitis Externa Episodes in Atopic Dogs Is Reduced by a Therapeutic Diet in a 6-Month Randomised, Blinded, Controlled, Clinical Trial.Veterinary dermatology · 2026Article
- Polyunsaturated fatty acids in biotechnology and health: Sources, Synthesis, Applications, and market trends.Archives of microbiology · 2026Review
87 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Omega-3 (ω-3) and omega-6 (ω-6) polyunsaturated fatty acids (PUFAs) are nowadays desirable components of oils with special dietary and functional properties. Their therapeutic and health-promoting effects have already been established in various chronic inflammatory and autoimmune diseases through various mechanisms, including modifications in cell membrane lipid composition, gene expression, cellular metabolism, and signal transduction. The application of ω-3 and ω-6 PUFAs in most common skin diseases has been examined in numerous studies, but their results and conclusions were mostly opposing and inconclusive. It seems that combined ω-6, gamma-linolenic acid (GLA), and ω-3 long-chain PUFAs supplementation exhibits the highest potential in diminishing inflammatory processes, which could be beneficial for the management of inflammatory skin diseases, such as atopic dermatitis, psoriasis, and acne. Due to significant population and individually-based genetic variations that impact PUFAs metabolism and associated metabolites, gene expression, and subsequent inflammatory responses, at this point, we could not recommend strict dietary and supplementation strategies for disease prevention and treatment that will be appropriate for all. Well-balanced nutrition and additional anti-inflammatory PUFA-based supplementation should be encouraged in a targeted manner for individuals in need to provide better management of skin diseases but, most importantly, to maintain and improve overall skin health.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.