ArticleScience immunology2020
Mutual inhibition between Prkd2 and Bcl6 controls T follicular helper cell differentiation.
Open access · greenAbstract read
In one paragraph
Article in Science immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Single-cell and bulk transcriptomics uncovers PRKD2-driven tumor stemness and progression in multiple myeloma.Scientific reports · 2025Article
- A hypomorphic Mpi mutation unlocks an in vivo tool for studying global N-glycosylation deficiency.JCI insight · 2025Article
- Augmenting flexibility: mutual inhibition between inhibitory neurons expands functional diversity.iScience · 2025Article
- PRKD2 as a novel target for targeting the diabetes-osteoporosis nexus.Scientific reports · 2025Article
- Fine-mapping and molecular characterisation of primary sclerosing cholangitis genetic risk loci.Nature communications · 2024Article
- Help me help you: emerging concepts in T follicular helper cell differentiation, identity, and function.Current opinion in immunology · 2024Review
- The differentiation courses of the Tfh cells: a new perspective on autoimmune disease pathogenesis and treatment.Bioscience reports · 2024Review
- Addressing the role of PKD3 in the T cell compartment with knockout mice.Cell communication and signaling : CCS · 2022Article
- Naive and memory CD4iScience · 2022Article
- T cell-intrinsic protein kinase D3 is dispensable for the cells' activation.Frontiers in immunology · 2022Article
- The Differentiation and Maintenance of SARS-CoV-2-Specific Follicular Helper T Cells.Frontiers in cellular and infection microbiology · 2022Review
- Multifaceted Functions of Protein Kinase D in Pathological Processes and Human Diseases.Biomolecules · 2021Review
- Short or Long Interval between Priming and Boosting: Does It Impact on the Vaccine Immunogenicity?Vaccines · 2021Article
- Stepwise Tfh cell differentiation revisited: new advances and long-standing questions.Faculty reviews · 2021Article
- ZBTB Transcription Factors: Key Regulators of the Development, Differentiation and Effector Function of T Cells.Frontiers in immunology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors at 2 institutions in 2 countries.
Takuma MisawaCenter for the Genetics of Host Defense, UT Southwestern Medical Center, Dallas, TX 75390, USA. takuma.misawa@utsouthwestern.edu bruce.beutler@utsouthwestern.edu.ORCID 0000-0003-4642-6229
Jeffrey A SoRelleCenter for the Genetics of Host Defense, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Jin Huk ChoiCenter for the Genetics of Host Defense, UT Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0003-2483-4379
Tao YueCenter for the Genetics of Host Defense, UT Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0001-5417-2826
Kuan-Wen WangCenter for the Genetics of Host Defense, UT Southwestern Medical Center, Dallas, TX 75390, USA.
William McAlpineCenter for the Genetics of Host Defense, UT Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-4611-5968
Jianhui WangCenter for the Genetics of Host Defense, UT Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-6335-8355
Aijie LiuCenter for the Genetics of Host Defense, UT Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-4777-7795
Koichi TabetaDivision of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Science, Niigata, Japan.ORCID 0000-0002-7019-1872
Emre E TurerCenter for the Genetics of Host Defense, UT Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0001-8782-3648
Bret EversDivision of Neuropathology, UT Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0001-5686-0315
Evan Nair-GillCenter for the Genetics of Host Defense, UT Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-9876-7853
Subhajit PoddarCenter for the Genetics of Host Defense, UT Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-9764-3242
Lijing SuCenter for the Genetics of Host Defense, UT Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0003-1533-0988
Feiya OuCenter for the Genetics of Host Defense, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Liyang YuCenter for the Genetics of Host Defense, UT Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-7337-4420
Jamie RussellCenter for the Genetics of Host Defense, UT Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-9090-4067
Sara LudwigCenter for the Genetics of Host Defense, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Xiaoming ZhanCenter for the Genetics of Host Defense, UT Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0003-2045-5259
Sara HildebrandCenter for the Genetics of Host Defense, UT Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-5534-3604
Xiaohong LiCenter for the Genetics of Host Defense, UT Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0001-8357-5587
Miao TangCenter for the Genetics of Host Defense, UT Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-8708-3296
Anne R MurrayCenter for the Genetics of Host Defense, UT Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-5586-635X
Eva Marie Y MorescoCenter for the Genetics of Host Defense, UT Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-2049-7291
Bruce BeutlerCenter for the Genetics of Host Defense, UT Southwestern Medical Center, Dallas, TX 75390, USA. takuma.misawa@utsouthwestern.edu bruce.beutler@utsouthwestern.edu.ORCID 0000-0002-3639-246X
Southwestern Medical Center · USNiigata University · JP
Funding
Systems Biology CoreU19AI100627 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI NOLAN, GARRY P · 2012 to 2021
$49.1MAutomated Forward Genetic Analysis of Adaptive ImmunityR01AI125581 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI BRUCE A BEUTLER · 2016 to 2026
$19.5MMucosal Immune Defense Mechanisms of the Urinary BladderU01AI095542 · NIAID · WASHINGTON UNIVERSITY · PI COLONNA, MARCO, HULTGREN, SCOTT J. · 2011 to 2020
$9.8MINTEGRATIVE IMMUNOLOGY TRAINING PROGRAMT32AI005284 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Nan Yan · 2003 to 2026
$7.4MThe Role of the Smcr8-Wdr41-C9orf72 (SWC) Complex in the Maintenance of Intestinal HomeostasisR01DK119360 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI TURER, EMRE EROL · 2020 to 2023
$1.8MForward Genetic Analysis of Intestinal HomeostasisK08DK107886 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI TURER, EMRE EROL · 2016 to 2020
$740kNIAID NIH HHS R01 AI125581NIAID NIH HHS T32 AI005284NIAID NIH HHS U01 AI095542NIAID NIH HHS U19 AI100627NIDDK NIH HHS K08 DK107886NIDDK NIH HHS R01 DK119360
Abstract
T follicular helper cells (T
Indexed as
AnimalsB-LymphocytesBone Marrow TransplantationCD4-Positive T-LymphocytesCell DifferentiationFemaleGerminal CenterHEK293 CellsHumansImmunoglobulinsImmunotherapy, AdoptiveMaleMice, TransgenicMutationProtein Kinase D2Protein KinasesBcl6 protein, mouseImmunoglobulinsProtein Kinase D2Protein KinasesProto-Oncogene Proteins c-bcl-6
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.