Evidence map›Paper›PMID 31991246›Full record

ArticleNeurobiology of disease2020

FMRP regulates presynaptic localization of neuronal voltage gated calcium channels.

Laurent Ferron, Cesare G Novazzi, Kjara S Pilch, Cristian Moreno, Krishma Ramgoolam, Annette C Dolphin

Open access · goldAbstract read
In one paragraph

Article in Neurobiology of disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Involvement of CaThe Journal of physiology · 2022
    Article
  8. Article
  9. CaMolecular brain · 2022
    Article
  10. FMRP Sustains Presynaptic Function via Control of Activity-Dependent Bulk Endocytosis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  11. Genes · 2021
    Review
  12. Channelopathies in fragile X syndrome.Nature reviews. Neuroscience · 2021
    Review
  13. The life cycle of voltage-gated CaNeuronal signaling · 2021
    Review
  14. Hyperexcitability of Sensory Neurons in Fragile X Mouse Model.Frontiers in molecular neuroscience · 2021
    Article
  15. Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Laurent FerronDepartment of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK. Electronic address: l.ferron@ucl.ac.uk.
Cesare G NovazziDepartment of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK.
Kjara S PilchDepartment of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK.
Cristian MorenoDepartment of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK.
Krishma RamgoolamDepartment of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK.
Annette C DolphinDepartment of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK.
University College London · GB

Funding

Medical Research Council MR/J013285/1Wellcome TrustWellcome Trust 206279/Z/17/Z
6 · The paper itself

Abstract

Fragile X syndrome (FXS), the most common form of inherited intellectual disability and autism, results from the loss of fragile X mental retardation protein (FMRP). We have recently identified a direct interaction of FMRP with voltage-gated Ca

Indexed as

AnimalsCalciumCalcium ChannelsCalcium Channels, N-TypeFragile X Messenger Ribonucleoprotein 1Fragile X SyndromeNeuronsPresynaptic TerminalsSynaptic TransmissionCalciumCalcium ChannelsCalcium Channels, N-TypeFMR1 protein, humanFragile X Messenger Ribonucleoprotein 1Calcium transientsFragile X syndrome - FMRPSynaptic transmissionTraffickingVoltage-gated calcium channels

Identifiers

PMID31991246
PMCPMC7152798
OpenAlexW3002816544

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.