Evidence map›Paper›PMID 31992158›Full record

SynthesisJournal of the American Heart Association2020

Sodium-Glucose Cotransporter 2 Inhibition for the Prevention of Cardiovascular Events in Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.

Clare Arnott, Qiang Li, Amy Kang, Brendon L Neuen, Severine Bompoint, Carolyn S P Lam, Anthony Rodgers, Kenneth W Mahaffey, Christopher P Cannon, Vlado Perkovic and 2 more

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04549766 (The Predictive Value of PRECISE DAPT Score in Patients With ST Segment Elevation Myocardial Infarction), which is not on this map. Cited by 108 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed, 17 pooled it
26.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04549766 unknown statusnot on this map

The Predictive Value of PRECISE DAPT Score in Patients With ST Segment Elevation Myocardial Infarction (STEMI) After Primary Percutaneous Coronary Intervention (PPCI)

TypeobservationalSponsorAssiut UniversityRan2020 to 2025Enrolled150ConditionsST-segment Elevation Myocardial Infarction (STEMI)Armscalculate PRECISE DAPT score using clinical data
3 · Its place in the literature

Who cites it

108 citing papers in PubMed, 17 syntheses or guidelines pooled it, 251 citations in OpenAlex.

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48 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 4 countries.

Clare ArnottThe George Institute for Global Health University of New South Wales Sydney Australia.
Qiang LiThe George Institute for Global Health University of New South Wales Sydney Australia.
Amy KangThe George Institute for Global Health University of New South Wales Sydney Australia.
Brendon L NeuenThe George Institute for Global Health University of New South Wales Sydney Australia.
Severine BompointThe George Institute for Global Health University of New South Wales Sydney Australia.
Carolyn S P LamThe George Institute for Global Health University of New South Wales Sydney Australia.
Anthony RodgersThe George Institute for Global Health University of New South Wales Sydney Australia.
Kenneth W MahaffeyDepartment of Medicine Stanford Center for Clinical Research Stanford University School of Medicine Stanford CA.
Christopher P CannonCardiovascular Division Brigham and Women's Hospital and Baim Institute for Clinical Research Boston MA.
Vlado PerkovicThe George Institute for Global Health University of New South Wales Sydney Australia.
Meg J JardineThe George Institute for Global Health University of New South Wales Sydney Australia.
Bruce NealThe George Institute for Global Health University of New South Wales Sydney Australia.
The George Institute for Global Health · AUUNSW Sydney · AUBaim Institute for Clinical Research · USImperial College London · GBStanford University · USUniversity of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Several trials have demonstrated protective effects from inhibition of sodium-glucose cotransporter 2 among patients with type 2 diabetes mellitus. There is uncertainty about the consistency of the cardiovascular benefits achieved across patient subsets. Methods and Results We included 4 large-scale trials of sodium-glucose cotransporter 2 inhibition compared with placebo in patients with diabetes mellitus that reported effects on cardiovascular outcomes overall and for participant subgroups defined at baseline by cardiovascular disease, reduced kidney function, and heart failure. Fixed effects models with inverse variance weighting were used to estimate summary hazard ratios and 95% CIs. There were 38 723 patients from 4 trials, with a mean 2.9 years of follow-up. Of the patients, 22 870 (59%) had cardiovascular disease, 7754 (20%) had reduced kidney function, and 4543 (12%) had heart failure. There were 3828 major adverse cardiac events. There was overall benefit for major adverse cardiac events (0.88; 95% CI, 0.82-0.94;

Indexed as

AgedCardiovascular DiseasesDiabetes Mellitus, Type 2FemaleHeart Disease Risk FactorsHumansMaleMiddle AgedProtective FactorsRandomized Controlled Trials as TopicRisk AssessmentSodium-Glucose Transporter 2 InhibitorsTreatment OutcomeSodium-Glucose Transporter 2 Inhibitorscardiovascular diseasemeta‐analysissodium‐glucose cotransporter 2 inhibitiontype 2 diabetes mellitus

Identifiers

PMID31992158
PMCPMC7033896
OpenAlexW3003318708

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.