Evidence map›Paper›PMID 31992297›Full record

ArticleCardiovascular diabetology2020

Association of insulin resistance, from mid-life to late-life, with aortic stiffness in late-life: the Atherosclerosis Risk in Communities Study.

Anna K Poon, Michelle L Meyer, Hirofumi Tanaka, Elizabeth Selvin, James Pankow, Donglin Zeng, Laura Loehr, Joshua W Knowles, Wayne Rosamond, Gerardo Heiss

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular diabetology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Anna K PoonDepartment of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, USA. apoon@hsph.harvard.edu.ORCID http://orcid.org/0000-0001-6126-6126
Michelle L MeyerDepartment of Emergency Medicine, University of North Carolina School of Medicine, Chapel Hill, USA.
Hirofumi TanakaDepartment of Kinesiology and Health Education, University of Texas at Austin, Austin, USA.
Elizabeth SelvinDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA.
James PankowDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, USA.
Donglin ZengDepartment of Biostatistics, University of North Carolina Gillings School of Global Public Health, Chapel Hill, USA.
Laura LoehrDepartment of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, USA.
Joshua W KnowlesDepartment of Medicine and Cardiovascular Institute, Stanford University, Stanford, USA.
Wayne RosamondDepartment of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, USA.
Gerardo HeissDepartment of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, USA.
University of North Carolina at Chapel Hill · USCardiovascular Institute of the South · USJohns Hopkins University · USThe University of Texas at Austin · USUniversity of Minnesota · US

Funding

Stanford Islet Research CoreP30DK116074 · NIDDK · STANFORD UNIVERSITY · PI Seung K Kim · 2017 to 2026
$19.5M
Cardiovascular Epidemiology Training GrantT32HL007055 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Wayne D. Rosamond · 1986 to 2026
$10.0M
Diabetes and Prediabetes in Older Adults in ARICR01DK089174 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SELVIN, ELIZABETH · 2011 to 2020
$6.4M
Changes in arterial stiffness, cognition and dementia risk in a diverse cohortR01AG053938 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MEYER, MICHELLE · 2016 to 2020
$2.9M
Mechanisms of NAT2 Regulation of Insulin Resistance and Mitochondrial DysfunctionR01DK116750 · NIDDK · STANFORD UNIVERSITY · PI KNOWLES, JOSHUA WILEY · 2019 to 2023
$2.4M
Beyond GWAS of insulin resistance: An integrated approach to translate genetic association to functionR01DK106236 · NIDDK · STANFORD UNIVERSITY · PI KNOWLES, JOSHUA WILEY · 2016 to 2020
$2.4M
Causal associations of circulating biomarkers with cardiovascular diseaseR01HL135313 · NHLBI · STANFORD UNIVERSITY · PI INGELSSON, ERIK · 2017 to 2019
$1.6M
Research and Mentoring in the Clinical Epidemiology of Type 2 DiabetesK24DK106414 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SELVIN, ELIZABETH · 2015 to 2019
$654k
NHLBI NIH HHS 2 T32 HL 7055NHLBI NIH HHS HHSN268201700001CNHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002CNHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003CNHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700004CNHLBI NIH HHS HHSN268201700004INHLBI NIH HHS HHSN268201700005CNHLBI NIH HHS HHSN268201700005INHLBI NIH HHS R01 HL135313NHLBI NIH HHS T32 HL007055NIA NIH HHS R01 AG053938NIA NIH HHS R01AG053938NIDDK NIH HHS K24 DK106414NIDDK NIH HHS P30 DK116074NIDDK NIH HHS R01 DK089174NIDDK NIH HHS R01 DK106236NIDDK NIH HHS R01 DK116750NIH HHS 1R01DK106236NIH HHS 1R01HL135313Stanford Diabetes Research Center P30DK116074
6 · The paper itself

Abstract

backgroundInsulin resistance may contribute to aortic stiffening that leads to end-organ damage. We examined the cross-sectional association and prospective association of insulin resistance and aortic stiffness in older adults without diabetes.

methodsWe analyzed 2571 men and women at Visit 5 (in 2011-2013), and 2350 men and women at repeat examinations from baseline at Visit 1 (in 1987-1989) to Visit 5 (in 2011-2013). Linear regression was used to estimate the difference in aortic stiffness per standard unit of HOMA-IR, TG/HDL-C, and TyG at Visit 5. Linear mixed effects were used to assess if high, as opposed to non-high, aortic stiffness (> 75th percentile) was preceded by a faster annual rate of change in log-HOMA-IR, log-TG/HDL-C, and log-TyG from Visit 1 to Visit 5.

resultsThe mean age of participants was 75 years, 37% (n = 957) were men, and 17% (n = 433) were African American. At Visit 5, higher HOMA-IR, higher TG/HDL-C, and higher TyG were associated with higher aortic stiffness (16 cm/s per SD (95% CI 6, 27), 29 cm/s per SD (95% CI 18, 40), and 32 cm/s per SD (95% CI 22, 42), respectively). From Visit 1 to Visit 5, high aortic stiffness, compared to non-high aortic stiffness, was not preceded by a faster annual rate of change in log-HOMA-IR from baseline to 9 years (0.030 (95% CI 0.024, 0.035) vs. 0.025 (95% CI 0.021, 0.028); p = 0.15) or 9 years onward (0.011 (95% CI 0.007, 0.015) vs. 0.011 (95% CI 0.009, 0.013); p = 0.31); in log-TG/HDL-C from baseline to 9 years (0.019 (95% CI 0.015, 0.024) vs. 0.024 (95% CI 0.022, 0.026); p = 0.06) or 9 years onward (- 0.007 (95% CI - 0.010, - 0.005) vs. - 0.009 (95% CI - 0.010, - 0.007); p = 0.08); or in log-TyG from baseline to 9 years (0.002 (95% CI 0.002, 0.003) vs. 0.003 (95% CI 0.003, 0.003); p = 0.03) or 9 years onward (0 (95% CI 0, 0) vs. 0 (95% CI 0, 0); p = 0.08).

conclusionsAmong older adults without diabetes, insulin resistance was associated with aortic stiffness, but the putative role of insulin resistance in aortic stiffness over the life course requires further study.

Indexed as

AgingInsulin ResistanceVascular StiffnessAgedAge FactorsBiomarkersBlood GlucoseCardiovascular DiseasesCross-Sectional StudiesFemaleHumansInsulinLipidsMalePrognosisProspective StudiesBiomarkersBlood GlucoseInsulinLipidsAortic stiffnessArterial stiffnessCarotid-femoral pulse wave velocityHomeostatic model assessment of insulin resistanceInsulin resistanceTriglyceride and glucose indexTriglyceride to high-density lipoprotein cholesterol ratio

Identifiers

PMID31992297
PMCPMC6986071
OpenAlexW3005597180

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.