ArticleCell reports2020
Treg-Cell-Derived IL-35-Coated Extracellular Vesicles Promote Infectious Tolerance.
Open access · goldAbstract read
In one paragraph
Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers.
0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed
7.7field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
109 citing papers in PubMed, 155 citations in OpenAlex.
- IL35 Production After Living-donor Renal Transplantation: Relevance to Local, Exosome-mediated, Clinical Tolerance.Transplantation direct · 2026Article
- The Framework of Host Innate and Adaptive Immunological Pathways.Biomedicines · 2026Review
- Regulatory T cells in cancer and inflammation.Signal transduction and targeted therapy · 2026Review
- In Vitro Evaluation of Necrostatin-1 Microparticles for Limiting Stress-induced Cell Death and Preserving Islet Function.Transplantation direct · 2026Article
- Novel perspectives on extracellular vesicles in autoimmune diseases: immunogenicity, inflammation, and immune surveillance.The Journal of clinical investigation · 2026Review
- LAG-3Immunology · 2026Article
- IL-35 enhances IL-10⁺ breg-mediated immunoregulation and attenuates inflammation and fibrosis in systemic sclerosis.Arthritis research & therapy · 2026Article
- The progress and perspective of nanomedicine in modulating the tumor immune microenvironment.Acta pharmaceutica Sinica. B · 2026Review
- Research progress on the roles of extracellular vesicles in tumor immunity and drug resistance.Frontiers in immunology · 2026Review
- The Role of MicroRNAs in Treg-Derived Extracellular Vesicles: A Narrative Review Focusing on Immune-Related Diseases.Journal of immunology research · 2026Review
- Interleukin-35 as a key immunoregulatory mediator in steroid-hyporesponsive severe asthma.Frontiers in immunology · 2026Review
- The crosstalk between nerves and immunity: chronic stress as a driver of tumor progression.Frontiers in immunology · 2026Review
- Innovative research on predicting skin flaps necrosis through quantification of the USP4/TNFAIP2 regulated 'M1 macrophages-Tregs axis' via skin barrier monitoring technology.Burns & trauma · 2026Article
- How Cytokines Regulate Immune Response Toward Chronic Allograft Rejection?Results and problems in cell differentiation · 2026Review
- Extracellular vesicles for macrophage reprogramming: an emerging paradigm in immunomodulatory therapeutics.Journal of biological engineering · 2025Review
- Leptin decreases Th17/Treg ratio to facilitate neuroblastoma via inhibiting long-chain fatty acid catabolism in tumor cells.Oncoimmunology · 2025Article
- Mouse TThe Journal of allergy and clinical immunology · 2025Article
- Regulatory T cell therapy in solid organ transplantation: clinical applications and laboratory monitoring strategies.Clinical transplantation and research · 2025Review
- Induced Treg-Derived Extracellular Vesicles Suppress CD4Journal of extracellular vesicles · 2025Article
- The Role and Potential Application of IL-12 in the Immune Regulation of Tuberculosis.International journal of molecular sciences · 2025Review
49 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 4 institutions in 2 countries.
Jeremy A SullivanDepartment of Surgery, Division of Transplantation, University of Wisconsin-Madison, Madison, WI, USA. Electronic address: sullivan@surgery.wisc.edu.
Yusuke TomitaDepartment of Surgery, Division of Transplantation, University of Wisconsin-Madison, Madison, WI, USA.
Ewa Jankowska-GanDepartment of Surgery, Division of Transplantation, University of Wisconsin-Madison, Madison, WI, USA.
Diego A LemaDepartment of Surgery, Division of Transplantation, University of Wisconsin-Madison, Madison, WI, USA.
Matt P ArvedsonDepartment of Surgery, Division of Transplantation, University of Wisconsin-Madison, Madison, WI, USA.
Ashita NairPharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, USA.
William Bracamonte-BaranDepartment of Surgery, Division of Transplantation, University of Wisconsin-Madison, Madison, WI, USA.
Ying ZhouDepartment of Surgery, Division of Transplantation, University of Wisconsin-Madison, Madison, WI, USA.
Kristy K MeyerDepartment of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA; Pathology and Laboratory Services, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.
Weixiong ZhongDepartment of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA; Pathology and Laboratory Services, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.
Deepali V SawantDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Andrea L Szymczak-WorkmanDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Qianxia ZhangDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Creg J WorkmanDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Seungpyo HongPharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, USA; Yonsei Frontier Lab and Department of Pharmacy, Yonsei University, Seoul, Korea.
Dario A A VignaliDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
William J BurlinghamDepartment of Surgery, Division of Transplantation, University of Wisconsin-Madison, Madison, WI, USA.
University of Wisconsin–Madison · USUniversity of Pittsburgh · USUPMC Hillman Cancer Center · USWilliam S. Middleton Memorial Veterans Hospital · US
Funding
VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOHN C. BYRD · 1988 to 2026
$158.0MUW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6MInterleukin-35 and the tumor microenvironmentR01CA203689 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VIGNALI, DARIO AA · 2016 to 2020
$1.9MNatural vs. Pathogenic Th17 responses to col Va1, Ka1tubulin and vimentinR01AI119140 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI SULLIVAN, JEREMY A · 2016 to 2020
$1.9MExosome-mediated Tolerance in combined Kidney and Stem Cell TransplantationR21AI147157 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI FOLEY, DAVID PAUL · 2019 to 2020
$426kDetection of IL35+ Exosomes as a Marker for Peripheral ToleranceR03AI146688 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI FOLEY, DAVID PAUL · 2020 to 2021
$155kNCI NIH HHS P30 CA014520NCI NIH HHS P30 CA047904NCI NIH HHS R01 CA203689NIAID NIH HHS R01 AI119140NIAID NIH HHS R03 AI146688NIAID NIH HHS R21 AI147157
Abstract
Interleukin-35 (IL-35) is an immunosuppressive cytokine composed of Epstein-Barr-virus-induced protein 3 (Ebi3) and IL-12α chain (p35) subunits, yet the forms that IL-35 assume and its role in peripheral tolerance remain elusive. We induce CBA-specific, IL-35-producing T regulatory (Treg) cells in Treg
Indexed as
Immune ToleranceAnimalsB-LymphocytesCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCoculture TechniquesExtracellular VesiclesFemaleForkhead Transcription FactorsGene Knockout TechniquesHeart TransplantationImmunosuppression TherapyInterleukin-12 Subunit p35InterleukinsMiceMice, Inbred C57BLEbi3 protein, mouseForkhead Transcription FactorsFoxp3 protein, mouseInterleukin-12 Subunit p35interleukin-35, mouseInterleukinsMinor Histocompatibility AntigensReceptors, CytokineCD81cytokinesEbi3exosomeextracellular vesiclesIL-35p35tetraspanintoleranceTreg
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.