Evidence map›Paper›PMID 31996124›Full record

ArticleMolecular medicine (Cambridge, Mass.)2020

NGF (-198C > T, Ala35Val) and p75

Leonn Mendes Soares Pereira, Ednelza da Silva Graça Amoras, Simone Regina Souza da Silva Conde, Sâmia Demachki, Eduardo José Melo Dos Santos, Sandra Souza Lima, Ricardo Ishak, Antonio Carlos Rosário Vallinoto

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine (Cambridge, Mass.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Association of theViruses · 2022
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Leonn Mendes Soares PereiraVirology Laboratory, Biological Science Institute, Federal University of Pará, Belém, Pará, Brazil.
Ednelza da Silva Graça AmorasVirology Laboratory, Biological Science Institute, Federal University of Pará, Belém, Pará, Brazil.
Simone Regina Souza da Silva CondeSchool of Medicine, Health Science Institute, Federal University of Pará, Belém, Pará, Brazil.
Sâmia DemachkiSchool of Medicine, Health Science Institute, Federal University of Pará, Belém, Pará, Brazil.
Eduardo José Melo Dos SantosPostgraduate Program in Biology of Infectious and Parasitic Agents, Biological Science Institute, Federal University of Pará, Belém, Pará, Brazil.
Sandra Souza LimaVirology Laboratory, Biological Science Institute, Federal University of Pará, Belém, Pará, Brazil.
Ricardo IshakVirology Laboratory, Biological Science Institute, Federal University of Pará, Belém, Pará, Brazil.
Antonio Carlos Rosário VallinotoVirology Laboratory, Biological Science Institute, Federal University of Pará, Belém, Pará, Brazil. vallinoto@ufpa.com.
Universidade Federal do Pará · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundsNeural growth factor (NGF) is a neurotrophin that can interact with the p75

methodsThe SNPs -198C > T, Arg80Gln, Val72Met, Ala35Val, Ala18Ala and Ser205Leu were genotyped by real-time PCR in samples from patients with chronic viral hepatitis stratified by stage of inflammation and liver fibrosis. Histopathological, viral load (VL), liver enzyme and comorbidities data were obtained from updated medical records. Other aspects were highlighted by applied epidemiological questionnaires.

resultsThe -198C/T and Ala35Val polymorphisms in NGF were associated with changes in histopathological profiles, VL and liver enzymes. Ser205Leu polymorphism in p75

conclusionMutations in the NGF (-198C > T, Ala35Val) and p75

Indexed as

Amino Acid SubstitutionCross-Sectional StudiesFemaleHepatitis, Viral, HumanHumansLiver Function TestsMaleNerve Growth FactorNerve Tissue ProteinsPolymorphism, Single NucleotideReceptors, Nerve Growth FactorViral LoadNerve Growth FactorNerve Tissue ProteinsNGF protein, humanNGFR protein, humanReceptors, Nerve Growth FactorBrazilian AmazonHepatic physiopathologyLiver diseasesNeurotrophinsPolymorphisms

Identifiers

PMID31996124
PMCPMC6990582
OpenAlexW3013980529

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.