ArticleWorld journal of surgical oncology2020
How does lymph node yield affect survival outcomes of stage I and II colon cancer?
Article in World journal of surgical oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- [Evidence for the extent and oncological benefits of lymphadenectomy in colon and rectal cancer : A narrative review based on meta-analyses].Chirurgie (Heidelberg, Germany) · 2025Pooled it
- Pooled it
- Perioperative and Oncological Outcomes of Colorectal Cancer Surgery in Obese Patients: A Multicenter Retrospective Study.Annals of gastroenterological surgery · 2026Article
- Prognostic and Predictive Role of Lymph Node Count in Stage II Colon Cancer: A Retrospective Analysis of a Japanese Nationwide Cohort.Annals of gastroenterological surgery · 2026Article
- More is not always better: higher lymph node yield is not associated with improved survival in stage I-III colorectal cancer.Frontiers in oncology · 2026Article
- Oncological merits of intracorporeal anastomosis versus extracorporeal anastomosis for right-sided colon cancer.Surgery today · 2025Article
- Transitioning to da Vinci Xi for colorectal cancer surgery: a prospective cohort study of 102 cases from a UK centre with a structured robotic programme.Journal of robotic surgery · 2025Article
- Article
- Determining the optimal number of examined lymph nodes for prognosis in colon cancer: a population-based study stratified by tumor location and T stage.Journal of gastrointestinal oncology · 2025Article
- Algorithm-based analysis of lymph node dissection strategies and survival outcomes in primary oral squamous cell carcinoma.Frontiers in oncology · 2025Article
- Article
- Immune microenvironment and lymph node yield in colorectal cancer.British journal of cancer · 2023Article
- Comparison of robotic versus laparoscopic right colectomy node retrieval in the obese population.Journal of robotic surgery · 2023Article
- Operative and Pathological Factors in Right-Sided Colon Cancers: How Can We Improve the Outcomes?Cureus · 2023Article
- Cost-effectiveness of precision molecular diagnostic tests for stage II colorectal cancer.Annals of translational medicine · 2022Article
- Is a cutoff value of 12 still useful in stage II right-sided colon cancer without risk factors?Korean journal of clinical oncology · 2022Article
- Primary tumour immune response and lymph node yields in colon cancer.British journal of cancer · 2022Article
- Robotic versus laparoscopic anterior resections for rectal and rectosigmoid cancer: an institutional experience.Irish journal of medical science · 2022Article
- Current Perspectives on the Importance of Pathological Features in Prognostication and Guidance of Adjuvant Chemotherapy in Colon Cancer.Current oncology (Toronto, Ont.) · 2022Article
- Improved Accuracy of Lymph Node Staging and Long-Term Survival Benefit in Colorectal Cancer WithPathology oncology research : POR · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAccording to the American Joint Committee on Cancer staging for cancer of the colon, a minimum of 12 lymph nodes (LN) has to be sampled for accurate staging. This has bearing on the long-term prognosis and the need for adjuvant chemotherapy. The aim of this study was to revisit the association of lymph node yield and the long-term survival in patients with stages I and II, i.e. node-negative, colon cancer.
methodConsecutive patients who underwent elective or emergency curative resections for cancer of colon between the years 2003 and 2012 were retrospectively reviewed. Only patients with stage I or II diseases (AJCC 8th edition) were included. They were analysed in three groups, LN<12, LN12-19 and LN≥20. Their clinic-pathological characteristics were compared. The disease-free (DFS) and overall survival (OS) were estimated with the Kaplan-Meier method and compared with the log-rank test.
resultsThere was a total of 659 patients included in the analysis. Twelve or more LN were found in 65.6% of the specimens. The mean follow-up was 83.9 months. LN≥20 had significantly better DFS (p = 0.015) and OS (p = 0.036), whereas LN<12 had similar DFS and OS when compared to LN12-19. The advantage in DFS and OS were mainly seen in those with stage II diseases. A lymph node yield of greater than 20 was one of the predictors of favourable DFS, hazard ratio 0.358; 95% CI 0.170-.756, p = 0.007.
conclusionThe lymph node yield had a significant association with survival outcomes. A lymph node yield of 20 or more was associated with better survival outcomes. On the other hand, lymph node yield less than 12 was not shown to have inferior survival outcomes when compared to those between 12 and 19.
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