Evidence mapPaperPMID 31997430Full record

Observational studyMicrocirculation (New York, N.Y. : 1994)2020

Higher levels of daily physical activity are associated with better skin microvascular function in type 2 diabetes-The Maastricht Study.

Ben M Sörensen, Frank C T van der Heide, Alfons J H M Houben, Annemarie Koster, Tos T J M Berendschot, Jan S A G Schouten, Abraham A Kroon, Carla J H van der Kallen, Ronald M A Henry, Martien C J M van Dongen and 6 more

Open access · hybridAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Microcirculation (New York, N.Y. : 1994), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Ben M SörensenCARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands.
Frank C T van der HeideCARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands.ORCID 0000-0003-1131-2184
Alfons J H M HoubenCARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands.
Annemarie KosterCAPHRI Care and Public Health Research Institute, Maastricht University, Maastricht, The Netherlands.
Tos T J M BerendschotUniversity Eye Clinic Maastricht, Maastricht University Medical Center+, Maastricht, The Netherlands.
Jan S A G SchoutenUniversity Eye Clinic Maastricht, Maastricht University Medical Center+, Maastricht, The Netherlands.
Abraham A KroonCARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands.
Carla J H van der KallenCARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands.
Ronald M A HenryCARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands.
Martien C J M van DongenCAPHRI Care and Public Health Research Institute, Maastricht University, Maastricht, The Netherlands.
Simone J P M EussenCARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands.
Hans H C M SavelbergNUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.
Julianne D van der BergCAPHRI Care and Public Health Research Institute, Maastricht University, Maastricht, The Netherlands.
Nicolaas C SchaperCARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands.
Miranda T SchramCARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands.
Coen D A StehouwerCARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands.
Maastricht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePhysical activity may provide a means for the prevention of cardiovascular disease via improving microvascular function. Therefore, this study investigated whether physical activity is associated with skin and retinal microvascular function.

methodsIn The Maastricht Study, a population-based cohort study enriched with type 2 diabetes (n = 1298, 47.3% women, aged 60.2 ± 8.1 years, 29.5% type 2 diabetes), we studied whether accelerometer-assessed physical activity and sedentary time associate with skin and retinal microvascular function. Associations were studied by linear regression and adjusted for major cardiovascular risk factors. In addition, we investigated whether associations were stronger in type 2 diabetes.

resultsIn individuals with type 2 diabetes, total physical activity and higher-intensity physical activity were independently associated with greater heat-induced skin hyperemia (regression coefficients per hour), respectively, 10 (95% CI: 1; 18) and 36 perfusion units (14; 58). In individuals without type 2 diabetes, total physical activity and higher-intensity physical activity were not associated with heat-induced skin hyperemia. No associations with retinal arteriolar %-dilation were identified.

conclusionHigher levels of total and higher-intensity physical activity were associated with greater skin microvascular vasodilation in individuals with, but not in those without, type 2 diabetes.

Indexed as

ExerciseMicrocirculationAdultAgedDiabetes Mellitus, Type 2FemaleHumansMaleMiddle AgedProspective StudiesSkincohort studiesdiabetes mellitusexercisemicrocirculationsedentary behaviortype 2

Identifiers

PMID31997430
PMCPMC7317394
OpenAlexW3003463986

What Socratic holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.