Evidence map›Paper›PMID 32006028›Full record

Trial reportThe Journal of nutrition2020

Lipid-Based Nutrient Supplementation Reduces Child Anemia and Increases Micronutrient Status in Madagascar: A Multiarm Cluster-Randomized Controlled Trial.

Christine P Stewart, Lia C H Fernald, Ann M Weber, Charles Arnold, Emanuela Galasso

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 3 pooled it
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.

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  15. Genomic prediction of zinc-biofortification potential in rice gene bank accessions.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Christine P StewartDepartment of Nutrition, University of California Davis, Davis, CA, USA.
Lia C H FernaldDivision of Community Health Sciences, School of Public Health, University of California Berkeley, Berkeley, CA, USA.
Ann M WeberSchool of Community Health Sciences, University of Nevada Reno, Reno, NV, USA.
Charles ArnoldDepartment of Nutrition, University of California Davis, Davis, CA, USA.
Emanuela GalassoDevelopment Research Group, The World Bank, Washington, DC, USA.
University of California, Davis · USBerkeley Public Health Division · USUniversity of Nevada, Reno · USWorld Bank Group · US

Funding

Effects of Supplementation and Stimulation on Child Development: the MAHAY studyR03HD091636 · NICHD · UNIVERSITY OF CALIFORNIA BERKELEY · PI FERNALD, LIA C. H. · 2018 to 2019
$138k
NICHD NIH HHS R03 HD091636
6 · The paper itself

Abstract

backgroundIron deficiency anemia affects hundreds of millions of women and children worldwide and is associated with impaired infant outcomes. Small-quantity lipid-based nutrient supplement (LNS) have been found to reduce the prevalence of anemia and iron deficiency in some trials.

objectivesWe evaluated the effectiveness of daily LNS supplementation on child anemia and micronutrient status in Madagascar within the context of an existing, scaled-up nutrition program.

methodsWe cluster-randomized 125 communities to (T0) a routine program with monthly growth monitoring and nutrition education; (T1) T0 + home visits for intensive nutrition counselling; (T2) T1 + LNS for children aged 6-18 mo; (T3) T2 + LNS for pregnant/lactating women; or (T4) T1 + parenting messages. Pregnant women and infants aged <12 mo were enrolled in 2014 and followed for 2 y. Child outcome measures included hemoglobin and anemia assessed using the HemoCue 301 system (n = 3561), and serum ferritin and soluble transferrin receptor as markers of iron status, retinol-binding protein as a marker of vitamin A status, and C-reactive protein and α-1 acid glycoprotein from a finger stick blood draw among a subsample (n = 387). We estimated mean difference using linear regression and prevalence ratios using modified Poisson regression accounting for the clustered design. All analyses were intention-to-treat.

resultsChildren in the LNS groups (T2 and T3) had ∼40% lower prevalence of anemia and iron deficiency anemia and 25% lower prevalence of iron deficiency than children in the control group (T0) (P < 0.05 for all). There were no differences in any of the biomarkers when comparing children in the T4 group with those in T0; nor were there differences between T3 and T2.

conclusionsOur findings suggest the provision of LNS in the context of a large-scale program offers significant benefits on anemia and iron status in young children.This trial was registered at www.isrctn.com as ISRCTN14393738.

Indexed as

Dietary SupplementsLipidsNutritional StatusAdultAnemiaChild, PreschoolCluster AnalysisFemaleHumansInfantInfant, NewbornLongitudinal StudiesMadagascarMicronutrientsPregnancyYoung AdultLipidsMicronutrientsanemiachildreniron deficiencylipid-based nutrient supplementMadagascarprogram evaluation

Identifiers

PMID32006028
PMCPMC7138674
OpenAlexW3003628143

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.