ArticlePflugers Archiv : European journal of physiology2020
Effects of high-intensity interval training on adipose tissue lipolysis, inflammation, and metabolomics in aged rats.
Article in Pflugers Archiv : European journal of physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Inflammatory markers and noncoding-RNAs responses to low and high compressions of HIIT with or without berberine supplementation in middle-aged men with prediabetes.Physiological reports · 2024Trial
- Exercise intensity modulates interorgan communication and is associated with cardiometabolic health outcomes in humans.Cell reports. Medicine · 2026Article
- Cognitive and biochemical responses to continuous moderate and extensive interval exercise in randomized elderly male rats.BMC sports science, medicine & rehabilitation · 2026Article
- Molecular mechanisms of exercise-induced improvements in Alzheimer's disease: a focus on lipid homeostasis.Translational neurodegeneration · 2026Review
- Exercise increases bone mass by lactate/Gpr81 signaling pathway.Communications biology · 2025Article
- Exercise intensity modulates the human plasma secretome and interorgan communication.bioRxiv : the preprint server for biology · 2025Article
- Exercise workload: a key determinant of immune health - a narrative review.Frontiers in immunology · 2025Review
- High-intensity interval training or lactate administration combined with aerobic training enhances visceral fat loss while promoting VMH neuroplasticity in female rats.Lipids in health and disease · 2024Article
- Beyond Calories: Individual Metabolic and Hormonal Adaptations Driving Variability in Weight Management-A State-of-the-Art Narrative Review.International journal of molecular sciences · 2024Review
- Effects of Life-Long Exercise on Age-Related Inflammation, Apoptosis, Oxidative Stress, Ferroptosis Markers, and NRF2/KAEP 1/Klotho Pathway in Rat Kidneys.Physiological research · 2024Article
- Effects of high-intensity interval training on lipid metabolism, tumor necrosis factor-α, and C-reactive proteinin overweight children.American journal of translational research · 2024Article
- High-intensity interval training induces lactylation of fatty acid synthase to inhibit lipid synthesis.BMC biology · 2023Article
- High intensity interval training attenuates osteoarthritis-associated hyperalgesia in rats.The journal of physiological sciences : JPS · 2023Article
- Elucidating the primary mechanisms of high-intensity interval training for improved cardiac fitness in obesity.Frontiers in physiology · 2023Review
- Long-term exercise pre-training attenuates Alzheimer's disease-related pathology in a transgenic rat model of Alzheimer's disease.GeroScience · 2022Article
- Comparison of visceral fat lipolysis adaptation to high-intensity interval training in obesity-prone and obesity-resistant rats.Diabetology & metabolic syndrome · 2022Article
- Exercise training remodels subcutaneous adipose tissue in adults with obesity even without weight loss.The Journal of physiology · 2022Article
- Immunological mechanisms of exercise therapy in dyslipidemia.Frontiers in physiology · 2022Review
- Lactate as Potential Mediators for Exercise-Induced Positive Effects on Neuroplasticity and Cerebrovascular Plasticity.Frontiers in physiology · 2021Review
- Post-exercise Effects and Long-Term Training Adaptations of Hormone Sensitive Lipase Lipolysis Induced by High-Intensity Interval Training in Adipose Tissue of Mice.Frontiers in physiology · 2020Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-intensity interval training (HIIT) is a time-efficient alternative to moderate-intensity continuous training (MICT) to improve metabolic health in older individuals. However, differences in adipose tissue metabolism between these two approaches are unclear. Here, we evaluated the effects of HIIT and MICT on metabolic phenotypes in aged rats. HIIT significantly decreased fat mass, increased percent lean mass, decreased fat-to-lean ratio, reduced serum high-sensitivity C-reactive protein, increased serum interleukin-10 levels, and decreased perirenal adipose tissue leptin compared with rats in the sedentary (SED) group. HIIT also increased pregnenolone, cortisol, and corticosterone in both adipose tissue and serum. Both exercise modalities enhanced hormone-sensitive lipase and adipose triglyceride lipase expression compared with the SED group and decreased palmitic acid, stearic acid, octadecadienoic acid, urea, 1-heptadecanol, and α-tocopherol. MICT was related to glycerolipid metabolism, whereas HIIT was related to steroid hormone biosynthesis. Overall, HIIT showed more favorable regulation of anti-inflammatory activity than MICT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.