Evidence map›Paper›PMID 32008085›Full record

ReviewCellular and molecular life sciences : CMLS2020

EMT signaling: potential contribution of CRISPR/Cas gene editing.

Reza Mohammadinejad, Alessio Biagioni, Ganesan Arunkumar, Rebecca Shapiro, Kun-Che Chang, Mohammed Sedeeq, Aftab Taiyab, Mohammad Hashemabadi, Abbas Pardakhty, Ali Mandegary and 3 more

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Review
  3. The Role of CRISPR and Its Therapeutic Applications in Glioblastoma.International journal of molecular sciences · 2026
    Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. EditingInternational journal of molecular sciences · 2021
    Review
  18. Review
  19. In vivo gene delivery mediated by non-viral vectors for cancer therapy.Journal of controlled release : official journal of the Controlled Release Society · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 10 institutions in 6 countries.

Reza MohammadinejadPharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Alessio BiagioniSection of Experimental Pathology and Oncology, Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Florence, Italy.
Ganesan ArunkumarCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Rebecca ShapiroDepartment of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada.
Kun-Che ChangDepartment of Ophthalmology, School of Medicine, Byers Eye Institute, Stanford University, Palo Alto, CA, 94303, USA.
Mohammed SedeeqDivision of Pharmacy, College of Health and Medicine, University of Tasmania, Hobart, TAS, Australia.
Aftab TaiyabDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, L8S 4L8, Canada.
Mohammad HashemabadiDepartment of Biology, Faculty of Sciences, Shahid Bahonar University, Kerman, Iran.
Abbas PardakhtyNeuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Ali MandegaryPhysiology Research Center, Institute of Neuropharmacology and Department of Toxicology & Pharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Jean-Paul ThieryGuangzhou Regenerative Medicine and Health, Guangdong Laboratory, Guangzhou, China.
Amir Reza ArefDepartment of Medical Oncology, Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, 02215, USA. Amir_aref@hms.harvard.edu.
Iman AzimiDivision of Pharmacy, College of Health and Medicine, University of Tasmania, Hobart, TAS, Australia. iman.azimi@utas.edu.au.ORCID http://orcid.org/0000-0001-9477-9999
Kerman University of Medical Sciences · IRUniversity of Tasmania · AUEuropean Society for Sexual Medicine · ITGuangzhou Regenerative Medicine and Health Guangdong Laboratory · CNHarvard University · USMcMaster University · CANational Institutes of Health · USShahid Bahonar University of Kerman · IRStanford University · USUniversity of Guelph · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epithelial to mesenchymal transition (EMT) is a complex plastic and reversible cellular process that has critical roles in diverse physiological and pathological phenomena. EMT is involved in embryonic development, organogenesis and tissue repair, as well as in fibrosis, cancer metastasis and drug resistance. In recent years, the ability to edit the genome using the clustered regularly interspaced palindromic repeats (CRISPR) and associated protein (Cas) system has greatly contributed to identify or validate critical genes in pathway signaling. This review delineates the complex EMT networks and discusses recent studies that have used CRISPR/Cas technology to further advance our understanding of the EMT process.

Indexed as

CRISPR-Cas SystemsEmbryonic DevelopmentEpithelial-Mesenchymal TransitionGene EditingHumansOrganogenesisSignal TransductionCancerCRISPREpithelial–mesenchymal transitionGene editing

Identifiers

PMID32008085
PMCPMC11104910
OpenAlexW3003606106

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.