Evidence map›Paper›PMID 32010345›Full record

ArticleActa endocrinologica (Bucharest, Romania : 2005)

PROTECTIVE EFFECT OF

E Altun, E Avci, T Yildirim, S Yildirim

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta endocrinologica (Bucharest, Romania : 2005). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Potential health benefits ofFrontiers in nutrition · 2022
    Review
  2. Biomolecules · 2021
    Review
  3. Black Cumin (Nutrients · 2021
    Review
  4. Effects ofFrontiers in pharmacology · 2021
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

E AltunBalikesir University, School of Medicine - Dept. of Pathology, Balikesir, Turkey.
E AvciBalikesir University, School of Medicine - Dept. of Cardiology, Balikesir University, School of Medicine, Turkey.
T YildirimBalikesir University, School of Medicine - Dept. of Cardiology, Balikesir University, School of Medicine, Turkey.
S YildirimAtaturk University - Faculty of Veterinary Medicine, Dept. of Pathology, Erzurum, Turkey.
Balıkesir University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo evaluate the protective effect of MATERIALS AND

methodsThirty-two 7-8-week-old female Wistar albino rats (300-350 g) were equally divided into 4 groups: nondiabetic untreated animals (control), diabetes mellitus (DM), NSO, and DM+NSO groups. For the induction of diabetes, 45 mg/kg streptozotocin was applied to the rats in the DM and DM+NSO groups as a single intraperitoneal dose. NSO (400 mg/kg) was orally administered through an intragastric catheter once a day over 21 days. Formalin-fixed, paraffin-embedded tissue sections of the myocardium were evaluated histopathologically and immunohistochemically.

resultsCompared to the control, NSO, and DM+NSO groups, the myocardial tissue samples from the rats in the DM group had significantly higher myositis, hyaline degeneration, and Zenker's necrosis. Moreover, the Bcl-2 expressions were significantly higher in the control, NSO, and DM+NSO groups than in the DM group.

conclusionNSO has a protective effect on the myocardium of streptozotocin-induced diabetic rats, most likely via suppressing apoptosis.

Indexed as

apoptosisBcl-2diabetes mellitusmyocardiumNigella sativa oil

Identifiers

PMID32010345
PMCPMC6992396
OpenAlexW3004242410

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.