ArticleJournal of health economics2020
Mendelian Randomization analysis of the causal effect of adiposity on hospital costs.
Article in Journal of health economics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed.
- Genetics identifies obesity as a shared risk factor for co-occurring multiple long-term conditions.Communications medicine · 2026Article
- Estimating the causal effect of cardiometabolic conditions on socioeconomic and healthcare outcomes: a scoping review of Mendelian randomization studies.Health economics review · 2026Article
- Associations of Alzheimer's disease with inpatient hospital costs and with quality-adjusted life years: evidence from conventional and Mendelian randomization analyses in the UK Biobank.Cost effectiveness and resource allocation : C/E · 2025Article
- Instrumental variables in the cost of illness featuring type 2 diabetes.Health services research · 2025Article
- Article
- Mendelian Randomization Analysis of the Causal Effect of Cigarette Smoking on Hospital Costs.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024Article
- Genetics-driven risk predictions leveraging the Mendelian randomization framework.Genome research · 2024Article
- Genomics and insurance in the United Kingdom: increasing complexity and emerging challenges.Health economics, policy, and law · 2024Article
- The healthcare costs of increased body mass index-evidence from The Trøndelag Health Study.Health economics review · 2024Article
- Causal Estimation of Long-term Intervention Cost-effectiveness Using Genetic Instrumental Variables: An Application to Cancer.Medical decision making : an international journal of the Society for Medical Decision Making · 2024Article
- Quantifying the causal impact of biological risk factors on healthcare costs.Nature communications · 2023Article
- A framework for assessing selection and misclassification bias in mendelian randomisation studies: an illustrative example between body mass index and covid-19.BMJ (Clinical research ed.) · 2023Article
- Integrating the Biology of Cardiovascular Disease into the Epidemiology of Economic Decision Modelling via Mendelian Randomisation.PharmacoEconomics · 2022Review
- A Mendelian randomization-based exploration of red blood cell distribution width and mean corpuscular volume with risk of hemorrhagic strokes.HGG advances · 2022Article
- Body mass index and healthcare costs: using genetic variants from the HUNT study as instrumental variables.BMC health services research · 2022Article
- Mendelian randomization.Nature reviews. Methods primers · 2022Article
- Mendelian Randomization: A Review of Methods for the Prevention, Assessment, and Discussion of Pleiotropy in Studies Using the Fat Mass and Obesity-Associated Gene as an Instrument for Adiposity.Frontiers in genetics · 2022Review
- Mendelian randomization analysis of the causal impact of body mass index and waist-hip ratio on rates of hospital admission.Economics and human biology · 2022Article
- Characterisation of insomnia as an environmental risk factor for asthma via Mendelian randomization and gene environment interaction.Scientific reports · 2021Article
- Effects of adiposity on the human plasma proteome: observational and Mendelian randomisation estimates.International journal of obesity (2005) · 2021Observational
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Estimates of the marginal effect of measures of adiposity such as body mass index (BMI) on healthcare costs are important for the formulation and evaluation of policies targeting adverse weight profiles. Most estimates of this association are affected by endogeneity bias. We use a novel identification strategy exploiting Mendelian Randomization - random germline genetic variation modelled using instrumental variables - to identify the causal effect of BMI on inpatient hospital costs. Using data on over 300,000 individuals, the effect size per person per marginal unit of BMI per year varied according to specification, including £21.22 (95% confidence interval (CI): £14.35-£28.07) for conventional inverse variance weighted models to £18.85 (95% CI: £9.05-£28.65) for penalized weighted median models. Effect sizes from Mendelian Randomization models were larger in most cases than non-instrumental variable multivariable adjusted estimates (£13.47, 95% CI: £12.51-£14.43). There was little evidence of non-linearity. Within-family estimates, intended to address dynastic biases, were imprecise.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.