ArticleNature communications2020
Two-stage electro-mechanical coupling of a K
Abstract read
In one paragraph
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed.
- Structural and kinetic mechanisms of state-dependent potassium channel inhibition.Science advances · 2026Article
- Article
- Barium senses subtle pore changes in a voltage-gated KScience advances · 2026Article
- PIPNature communications · 2026Article
- Allosteric Mechanisms Underlying Long QT Syndrome Type 2 (LQT2)-Associated Mutations in hERG Channels.bioRxiv : the preprint server for biology · 2026Article
- Two-step voltage-sensor activation of the human KNature communications · 2026Article
- Mapping the Functional Landscape ofmedRxiv : the preprint server for health sciences · 2025Article
- Secondary structure transitions and dual PIP2 binding define cardiac KCNQ1-KCNE1 channel gating.Cell research · 2025Article
- Electrophysiological characterization of the state-dependent inhibition of Kv7.1 and IMolecular pharmacology · 2025Article
- PIPResearch square · 2025Article
- A physiologically-relevant intermediate state structure of a voltage-gated potassium channel.Nature communications · 2025Article
- Article
- Voltage sensors.Molecular pharmacology · 2025Review
- The endocannabinoid ARA-S facilitates the activation of cardiac Kv7.1/KCNE1 channels from different species.Channels (Austin, Tex.) · 2024Article
- The fully activated open state of KCNQ1 controls the cardiac "fight-or-flight" response.PNAS nexus · 2024Article
- Targeting the ICirculation research · 2024Article
- A small-molecule activation mechanism that directly opens the KCNQ2 channel.Nature chemical biology · 2024Article
- Evaluating sequential and allosteric activation models in IKs channels with mutated voltage sensors.The Journal of general physiology · 2024Article
- A structurally precise mechanism links an epilepsy-associatedProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Isothermal Titration Calorimetry for Fragment-Based Analysis of Ion Channel Interactions.Methods in molecular biology (Clifton, N.J.) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Panpan HouDepartment of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University in St. Louis, St. Louis, MO, 63130, USA.ORCID http://orcid.org/0000-0001-7694-2262
Po Wei KangDepartment of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University in St. Louis, St. Louis, MO, 63130, USA.
Audrey Deyawe KongmeneckUniversité de Lorraine, CNRS, LPCT, 53000, Nancy, France.
Nien-Du YangDepartment of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University in St. Louis, St. Louis, MO, 63130, USA.ORCID http://orcid.org/0000-0002-5261-7382
Yongfeng LiuDepartment of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University in St. Louis, St. Louis, MO, 63130, USA.
Jingyi ShiDepartment of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University in St. Louis, St. Louis, MO, 63130, USA.
Xianjin XuDalton Cardiovascular Research Center, Department of Physics and Astronomy, Department of Biochemistry, Informatics Institute, University of Missouri - Columbia, Columbia, MO, 65211, USA.
Kelli McFarland WhiteDepartment of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University in St. Louis, St. Louis, MO, 63130, USA.
Mark A ZaydmanDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Marina A KasimovaUniversité de Lorraine, CNRS, LPCT, 53000, Nancy, France.ORCID http://orcid.org/0000-0002-7497-9448
Guiscard SeebohmInstitute for Genetics of Heart Diseases (IfGH), Department of Cardiovascular Medicine, University Hospital Münster, 48149, Münster, Germany.
Ling ZhongDepartment of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University in St. Louis, St. Louis, MO, 63130, USA.
Xiaoqin ZouDalton Cardiovascular Research Center, Department of Physics and Astronomy, Department of Biochemistry, Informatics Institute, University of Missouri - Columbia, Columbia, MO, 65211, USA.
Mounir TarekUniversité de Lorraine, CNRS, LPCT, 53000, Nancy, France. mounir.tarek@univ-lorraine.fr.
Jianmin CuiDepartment of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University in St. Louis, St. Louis, MO, 63130, USA. jcui@wustl.edu.
Funding
MANIPULATING IKS AS A THERAPEUTIC APPROACH TO CARDIAC ARRHYTHMIASR01HL126774 · NHLBI · WASHINGTON UNIVERSITY · PI CUI, JIANMIN · 2015 to 2018
$3.1MKCNQ CHANNELS: GATING AND SUBUNITS MODULATIONR01NS092570 · NINDS · WASHINGTON UNIVERSITY · PI SILVA, JONATHAN R · 2015 to 2020
$1.7MDatabase and software development for protein-nucleic acid structure predicationR01GM109980 · NIGMS · UNIVERSITY OF MISSOURI-COLUMBIA · PI ZOU, XIAOQIN · 2015 to 2019
$1.5MAmerican Heart Association-American Stroke Association 18POST34030203NHLBI NIH HHS R01 HL126774NIGMS NIH HHS R01 GM109980NINDS NIH HHS R01 NS092570
Abstract
In voltage-gated potassium (K
Indexed as
HumansIon Channel GatingKCNQ1 Potassium ChannelMolecular Docking SimulationOocytesPotassium ChannelsPotassium Channels, Voltage-GatedProtein ConformationKCNQ1 Potassium ChannelPotassium ChannelsPotassium Channels, Voltage-Gated
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.