Evidence map›Paper›PMID 32016566›Full record

ArticleDiabetologia2020

Impact of sleep deprivation and high-fat feeding on insulin sensitivity and beta cell function in dogs.

Annelies Brouwer, Isaac Asare Bediako, Rebecca L Paszkiewicz, Cathryn M Kolka, Richard N Bergman, Josiane L Broussard

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetologia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Annelies BrouwerSleep and Metabolism Laboratory, Department of Health and Exercise Science, Colorado State University, 1582 Campus Delivery, Fort Collins, CO, 80523-1582, USA.
Isaac Asare BediakoDiabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Rebecca L PaszkiewiczDiabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Cathryn M KolkaDiabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Richard N BergmanDiabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Josiane L BroussardSleep and Metabolism Laboratory, Department of Health and Exercise Science, Colorado State University, 1582 Campus Delivery, Fort Collins, CO, 80523-1582, USA. Josiane.broussard@colostate.edu.
Cedars-Sinai Medical Center · USAmsterdam University Medical Centers · NL

Funding

QUANTITATION OF FACTORS REGULATING GLUCOSE TOLERANCER01DK029867 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MARILYN ADER · 1986 to 2026
$11.0M
QUANTITATIVE STUDIES OF METABOLIC ORGAN DYNAMICSR01DK027619 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BERGMAN, RICHARD NATHAN · 1986 to 2022
$6.2M
Quantitative Studies of Metabolic Organ DynamicsR37DK027619 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BERGMAN, RICHARD NATHAN · 2007 to 2016
$6.2M
Time-restricted feeding to mitigate metabolic impairments during circadian misalignmentR01DK125653 · NIDDK · COLORADO STATE UNIVERSITY · PI BROUSSARD, JOSIANE · 2020 to 2024
$3.3M
Effects of physical activity on cardiometabolic impairments associated with insufficient sleepK01DK110138 · NIDDK · UNIVERSITY OF COLORADO · PI BROUSSARD, JOSIANE · 2016 to 2018
$484k
Impact of insufficient sleep on peripheral metabolic tissuesR03DK118309 · NIDDK · COLORADO STATE UNIVERSITY · PI BROUSSARD, JOSIANE · 2018 to 2019
$170k
NIDDK NIH HHS K01 DK110138NIDDK NIH HHS R01 DK027619NIDDK NIH HHS R01 DK029867NIDDK NIH HHS R01 DK125653NIDDK NIH HHS R01 DK29867NIDDK NIH HHS R03 DK118309NIDDK NIH HHS R37 DK027619
6 · The paper itself

Abstract

aims/hypothesisInsufficient sleep is increasingly recognised as a major risk factor for the development of obesity and diabetes, and short-term sleep loss in clinical studies leads to a reduction in insulin sensitivity. Sleep loss-induced metabolic impairments are clinically relevant, since reductions in insulin sensitivity after sleep loss are comparable to insulin sensitivity differences between healthy individuals and those with impaired glucose tolerance. However, the relative effects of sleep loss vs high-fat feeding in the same individual have not been assessed. In addition, to our knowledge no diurnal (active during the daytime) non-human mammalian model of sleep loss-induced metabolic impairment exists, which limits our ability to study links between sleep and metabolism.

methodsThis study examined the effects of one night of total sleep deprivation on insulin sensitivity and beta cell function, as assessed by an IVGTT, before and after 9 months of high-fat feeding in a canine model.

resultsOne night of total sleep deprivation in lean dogs impaired insulin sensitivity to a similar degree as a chronic high-fat diet (HFD)(normal sleep: 4.95 ± 0.45 mU CONCLUSIONS/

interpretationOur findings provide further evidence that sleep is important for metabolic health and establish a diurnal animal model of metabolic disruption during insufficient sleep.

Indexed as

Insulin ResistanceAnimalsDietary FatsDiet, High-FatDogsFeeding BehaviorGlucose IntoleranceInsulin-Secreting CellsMaleObesityRandom AllocationSleep DeprivationDietary FatsCanineDiabetesDietDogFatGlucoseInsulinObesitySleep

Identifiers

PMID32016566
PMCPMC7304935
OpenAlexW3005240315

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.