Evidence map›Paper›PMID 32017043›Full record

ArticleClinical pharmacology and therapeutics2020

Pediatric Extrapolation in Type 2 Diabetes: Future Implications of a Workshop.

Jeffrey S Barrett, Christina Bucci-Rechtweg, S Y Amy Cheung, Margaret Gamalo-Siebers, Sebastian Haertter, Janina Karres, Jan Marquard, Yeruk Mulugeta, Cecile Ollivier, Ashley Strougo and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Clinical pharmacology and therapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. A Review of Interventional Trials in Youth-Onset Type 2 Diabetes: Challenges and Opportunities.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 11 institutions in 6 countries.

Jeffrey S BarrettQuantitative Sciences, Bill & Melinda Gates Medical Research Institute, Cambridge, Massachusetts, USA.
Christina Bucci-RechtwegPediatric & Maternal Health Policy, Regulatory Affairs, Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA.
S Y Amy CheungCertara, Princeton, New Jersey, USA.
Margaret Gamalo-SiebersGlobal Statistical Sciences, Eli Lilly & Co., Indianapolis, Indiana, USA.
Sebastian HaertterTranslational Med & Clinical Pharmacology, Boehringer Ingelheim, Biberach, Germany.
Janina KarresPaediatric Medicines Office, European Medicines Agency, Amsterdam, The Netherlands.
Jan MarquardGlobal Clinical Development CardioMetabolism, Boehringer Ingelheim, Ingelheim, Germany.
Yeruk MulugetaDivision of Pediatric and Maternal Health, Office of New Drugs, Center for Drug Evaluation and Research, Washington, DC, USA.
Cecile OllivierAparito, Leiden, The Netherlands.
Ashley StrougoTranslational Medicine, Pharmacokinetics, Dynamics and Metabolism, Sanofi, Frankfurt, Germany.
Lisa YanoffDivision of Metabolism and Endocrinology Products, Office of New Drugs, Center for Drug Evaluation and Research, Washington, DC, USA.
Lynne YaoDivision of Pediatric and Maternal Health, Office of New Drugs, Center for Drug Evaluation and Research, Washington, DC, USA.
Philip ZeitlerDepartment of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA.
Center for Drug Evaluation and Research · USBill & Melinda Gates Foundation · USBioMarin (Netherlands) · NLBoehringer Ingelheim (Egypt) · EGBoehringer Ingelheim (Germany) · DECertara (United States) · USEli Lilly (United States) · USEuropean Medicines Agency · NLNovartis (Switzerland) · CHSanofi (France) · FRUniversity of Colorado Denver · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extrapolation from adults to youth with type 2 diabetes (T2D) is challenged by differences in disease progression and manifestation. This manuscript presents the results of a mock-team workshop focused on examining the typical team-based decision process used to propose a pediatric development plan for T2D addressing the viability of extrapolation. The workshop was held at the American Society for Clinical Pharmacology and Therapeutics (ASCPT) in Orlando, Florida on March 21, 2018.

Indexed as

AdolescentAdultAge FactorsDiabetes Mellitus, Type 2Disease ProgressionEducationHumansHypoglycemic AgentsHypoglycemic Agents

Identifiers

PMID32017043
PMCPMC7383960
OpenAlexW3004998947

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.