Evidence map›Paper›PMID 32017676›Full record

ArticleMicrobial genomics2020

The chromatin bound proteome of the human malaria parasite.

Gayani Batugedara, Xueqing M Lu, Anita Saraf, Mihaela E Sardiu, Anthony Cort, Steven Abel, Jacques Prudhomme, Michael P Washburn, Laurence Florens, Evelien M Bunnik and 1 more

Open access · goldAbstract read
In one paragraph

Article in Microbial genomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. eLife · 2024
    Article
  4. bioRxiv : the preprint server for biology · 2024
    Article
  5. Article
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Gayani BatugedaraDepartment of Molecular, Cell and Systems Biology, University of California Riverside, Riverside, CA 92521, USA.
Xueqing M LuDepartment of Molecular, Cell and Systems Biology, University of California Riverside, Riverside, CA 92521, USA.
Anita SarafStowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, MO 64110, USA.
Mihaela E SardiuStowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, MO 64110, USA.
Anthony CortDepartment of Molecular, Cell and Systems Biology, University of California Riverside, Riverside, CA 92521, USA.
Steven AbelDepartment of Molecular, Cell and Systems Biology, University of California Riverside, Riverside, CA 92521, USA.
Jacques PrudhommeDepartment of Molecular, Cell and Systems Biology, University of California Riverside, Riverside, CA 92521, USA.
Michael P WashburnStowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, MO 64110, USA.
Laurence FlorensStowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, MO 64110, USA.
Evelien M BunnikDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Karine G Le RochDepartment of Molecular, Cell and Systems Biology, University of California Riverside, Riverside, CA 92521, USA.
University of California, Riverside · USStowers Institute for Medical Research · USThe University of Texas Health Science Center at San Antonio · US

Funding

Chromatin structure and control of gene expression in the human malaria parasiteR01AI136511 · NIAID · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI LE ROCH, KARINE GAELLE · 2018 to 2022
$3.4M
The spatial organization of the Plasmodium genome throughout its infectious cycleR01AI106775 · NIAID · UNIVERSITY OF WASHINGTON · PI LE ROCH, KARINE GAELLE, NOBLE, WILLIAM STAFFORD · 2013 to 2016
$1.8M
Inhibitor Reprogramming of a Human Histone Deacetylase Protein Interaction NetworkR01GM112639 · NIGMS · STOWERS INSTITUTE FOR MEDICAL RESEARCH · PI FLORENS, LAURENCE ALEXANDRA · 2016 to 2020
$1.6M
NIAID NIH HHS R01 AI106775NIAID NIH HHS R01 AI136511NIGMS NIH HHS R01 GM112639
6 · The paper itself

Abstract

Proteins interacting with DNA are fundamental for mediating processes such as gene expression, DNA replication and maintenance of genome integrity. Accumulating evidence suggests that the chromatin of apicomplexan parasites, such as

Indexed as

ChromatinGene Expression RegulationGenome, ProtozoanHumansMalaria, FalciparumPlasmodium falciparumProtein BindingProteomeProtozoan ProteinsChromatinProteomeProtozoan Proteinschromatin-associated proteinschromatin structurePlasmodium falciparumproteometopological data analysis

Identifiers

PMID32017676
PMCPMC7067212
OpenAlexW3004852499

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.