ArticleScientific reports2020
A New Function for Perivascular Adipose Tissue (PVAT): Assistance of Arterial Stress Relaxation.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 38 citations in OpenAlex.
- Review
- Role of adipose tissue in cardiovascular health and diseases.Chinese medical journal · 2026Review
- Female Dahl, but Not SS13Research square · 2026Article
- Presence and Variability of the Microbiome in Perivascular Adipose Tissue: A Whole-Genome Sequencing Study in Dahl SS Rats.Life (Basel, Switzerland) · 2026Article
- Surgical Induction of Mid-Thoracic Aortic Coarctation in Mice: A Reproducible Preclinical Model of Pressure-Induced Vascular Remodeling.Current protocols · 2026Article
- Combined aerobic and resistance exercise training restores perivascular adipose tissue function in the thoracic aorta of rats with heart failure.Clinical science (London, England : 1979) · 2025Article
- PVAT adipocyte: energizing, modulating, and structuring vascular function during normotensive and hypertensive states.American journal of physiology. Heart and circulatory physiology · 2025Review
- Mechanotransduction in the Perivascular Adipose Tissue.Arteriosclerosis, thrombosis, and vascular biology · 2025Review
- Differential roles of eosinophils in cardiovascular disease.Nature reviews. Cardiology · 2025Review
- Platelets Modulate Leukocyte Population Composition Within Perivascular Adipose Tissue.International journal of molecular sciences · 2025Article
- Dissecting Tunica Responsibility in Arterial Stress Relaxation: Smooth Muscle Need Not Apply.Journal of vascular research · 2025Article
- A Skeletal Muscle-Mediated Anticontractile Response on Vascular Tone: Unraveling the Lactate-AMPK-NOS1 Pathway in Femoral Arteries.Function (Oxford, England) · 2024Article
- Impact of Perivascular Adipose Tissue on Neointimal Formation Following Endovascular Placement.Journal of cardiovascular translational research · 2024Review
- Integrins play a role in stress relaxation of perivascular adipose tissue.Pharmacological research · 2024Article
- A cell atlas of thoracic aortic perivascular adipose tissue: a focus on mechanotransducers.American journal of physiology. Heart and circulatory physiology · 2024Article
- Early life thymectomy induces arterial dysfunction in mice.GeroScience · 2024Article
- Deletion of adipocyte NOS3 potentiates high-fat diet-induced hypertension and vascular remodelling via chemerin.Cardiovascular research · 2023Article
- Vasodilator Responses of Perivascular Adipose Tissue-Derived Hydrogen Sulfide Stimulated with L-Cysteine in Pregnancy Hypertension-Induced Endothelial Dysfunction in Rats.Antioxidants (Basel, Switzerland) · 2023Article
- A Cell Atlas of Thoracic Aortic Perivascular Adipose Tissue: a focus on mechanotransducers.bioRxiv : the preprint server for biology · 2023Article
- Obesity, Cardiovascular and Neurodegenerative Diseases: Potential Common Mechanisms.Physiological research · 2023Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
In health, PVAT secretes anti-contractile factors that relax the underlying artery. PVAT's contributions to vascular function include more than production of vasoactive substances. We hypothesized that PVAT benefits the artery by assisting the function of stress (-induced) relaxation. Thoracic aorta rings from Sprague Dawley rats were mounted in isolated tissue baths with (+) and without (-) PVAT. A cumulative length tension (0-6 grams) was generated. The tension to which the tissue stress relaxed over 30 minutes was recorded; the tension lost was stress relaxation. The presence of PVAT increased the amount of stress relaxation (final tension in mgs; aortic ring -PVAT = 4578 ± 190; aortic ring + PVAT = 2730 ± 274, p < 0.05). PVAT left attached but not encompassing the aorta provided no benefit in cumulative stress relaxation (aortic ring +/- PVAT = 4122 ± 176; p > 0.05 vs -PVAT). A PVAT ring separated from the aorta demonstrated more profound stress relaxation than did the aortic ring itself. Finally, PVAT-assisted stress relaxation was observed in an artery with white fat (superior mesenteric artery) and in aorta from both male and female of another rat strain, the Dahl S rat. Knowledge of this new PVAT function supports PVAT as an essential player in vascular health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.