Evidence map›Paper›PMID 32024231›Full record

ArticleInternational journal of molecular sciences2020

Bumetanide Suppression of Angiogenesis in a Rat Model of Oxygen-Induced Retinopathy.

Sibel Guzel, Charles L Cai, Taimur Ahmad, Michelle Quan, Gloria B Valencia, Jacob V Aranda, Kay D Beharry

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Aquaporins: a novel perspective in the treatment of lung diseases.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Sibel GuzelDepartment of Pediatrics, Division of Neonatal-Perinatal Medicine, State University of New York, Downstate Medical Center, Brooklyn, NY 11203, USA.
Charles L CaiDepartment of Pediatrics, Division of Neonatal-Perinatal Medicine, State University of New York, Downstate Medical Center, Brooklyn, NY 11203, USA.
Taimur AhmadDepartment of Pediatrics, Division of Neonatal-Perinatal Medicine, State University of New York, Downstate Medical Center, Brooklyn, NY 11203, USA.
Michelle QuanDepartment of Pediatrics, Division of Neonatal-Perinatal Medicine, State University of New York, Downstate Medical Center, Brooklyn, NY 11203, USA.
Gloria B ValenciaDepartment of Pediatrics, Division of Neonatal-Perinatal Medicine, State University of New York, Downstate Medical Center, Brooklyn, NY 11203, USA.
Jacob V ArandaDepartment of Pediatrics, Division of Neonatal-Perinatal Medicine, State University of New York, Downstate Medical Center, Brooklyn, NY 11203, USA.
Kay D BeharryDepartment of Pediatrics, Division of Neonatal-Perinatal Medicine, State University of New York, Downstate Medical Center, Brooklyn, NY 11203, USA.ORCID 0000-0002-4129-475X
State University of New York · US

Funding

Synergistic Pharmacologicjntervention for Prevention of ROP (SPIPROP STUDY)U54HD071594 · NICHD · SUNY DOWNSTATE MEDICAL CENTER · PI QU, JUN · 2011 to 2015
$3.6M
Eunice Kennedy Shriver National Institute of Child Health and Human Development U54HD071594
6 · The paper itself

Abstract

Aquaporins (AQPs) are involved in hypoxia-induced angiogenesis and retinal damage. Bumetanide is a diuretic agent, Na

Indexed as

Disease Models, AnimalAnimalsAnimals, NewbornAquaporin 4BumetanideDiureticsFemaleMaleNeovascularization, PathologicOxygenRatsRats, Sprague-DawleyRetinal NeovascularizationRetinopathy of PrematurityVascular Endothelial Growth Factor AAqp4 protein, ratAquaporin 4BumetanideDiureticsOxygenVascular Endothelial Growth Factor Avascular endothelial growth factor A, ratangiogenesisaquaporinsbumetanideinsulin-like growth factor-Iintermittent hypoxiaretinavascular endothelial growth factor

Identifiers

PMID32024231
PMCPMC7037744
OpenAlexW3003814606

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.