Evidence map›Paper›PMID 32024452›Full record

ArticleJournal of neurotrauma2020

Cumulative Influence of Inflammatory Response Genetic Variation on Long-Term Neurobehavioral Outcomes after Pediatric Traumatic Brain Injury Relative to Orthopedic Injury: An Exploratory Polygenic Risk Score.

Amery Treble-Barna, Valentina Pilipenko, Shari L Wade, Anil G Jegga, Keith Owen Yeates, H Gerry Taylor, Lisa J Martin, Brad G Kurowski

Open access · greenAbstract read
In one paragraph

Article in Journal of neurotrauma, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
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  3. Review
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  7. An update on pediatric traumatic brain injury.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023
    Review
  8. Review
  9. Review
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Amery Treble-BarnaDepartment of Physical Medicine and Rehabilitation, University of Pittsburgh School of Medicine, Pittsburgh, Pennslvania, USA.
Valentina PilipenkoDivision of Human Genetics, Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Shari L WadeDivision of Pediatric Rehabilitation Medicine, Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Anil G JeggaDivision of Biomedical Informatics, Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Keith Owen YeatesDepartment of Psychology, Alberta Children's Hospital Research Institute, and Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.
H Gerry TaylorAbigail Wexner Research Institute at Nationwide Children's Hospital, and Department of Pediatrics, The Ohio State University, Columbus, Ohio, USA.
Lisa J MartinDivision of Human Genetics, Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Brad G KurowskiDivision of Pediatric Rehabilitation Medicine, Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Cincinnati Children's Hospital Medical Center · USNationwide Children's Hospital · USUniversity of Calgary · CAUniversity of Pittsburgh · US

Funding

Rehabilitation Medicine Scientist Training (RMST) ProgramK12HD001097 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BONINGER, MICHAEL L. · 1995 to 2016
$14.1M
Institutional Career Development CoreKL2TR001856 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RAY, KRISTIN N, RUBIO, DORIS M · 2016 to 2025
$13.8M
PEDIATRIC NEUROINTENSIVE CARE AND RESUSCITATION RESEARCHT32HD040686 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Robert S B Clark, PATRICK M KOCHANEK · 2000 to 2026
$7.1M
Genetic and Environmental Influences on Recovery of Severe Pediatric Brain Injury.R01NS096053 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI KUROWSKI, BRAD G · 2016 to 2020
$2.9M
Epigenetic Influences on Neurobehavioral Recovery following Pediatric Traumatic Brain InjuryK01HD097030 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TREBLE-BARNA, AMERY · 2019 to 2023
$642k
Efficacy of Methylphenidate for Management of Long-term Attention Problems inTBIK23HD074683 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI KUROWSKI, BRAD G · 2013 to 2016
$426k
NCATS NIH HHS KL2 TR001856NICHD NIH HHS K01 HD097030NICHD NIH HHS K12 HD001097NICHD NIH HHS K23 HD074683NICHD NIH HHS T32 HD040686NINDS NIH HHS R01 NS096053
6 · The paper itself

Abstract

The addition of genetic factors to prognostic models of neurobehavioral recovery following pediatric traumatic brain injury (TBI) may account for unexplained heterogeneity in outcomes. The present study examined the cumulative influence of candidate genes involved in the inflammatory response on long-term neurobehavioral recovery in children with early childhood TBI relative to children with orthopedic injuries (OI). Participants were drawn from a prospective, longitudinal study evaluating outcomes of children who sustained TBI (

Indexed as

AdolescentAdolescent BehaviorBrain Injuries, TraumaticChildChild, PreschoolFemaleGenetic VariationHumansInflammation MediatorsLongitudinal StudiesMaleMultifactorial InheritanceNeuropsychological TestsParentsPolymorphism, Single NucleotideProspective StudiesInflammation Mediatorsbehaviorinflammatory responsepediatric brain injuryPRSTBI

Identifiers

PMID32024452
PMCPMC7307697
OpenAlexW3005356164

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.