ArticleNature2020
Patterns of somatic structural variation in human cancer genomes.
Erratum issuedOpen access · hybridAbstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 554 papers.
0numbers the graph read from it
0cells of the map it votes in
554citing papers in PubMed
52.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
554 citing papers in PubMed, 963 citations in OpenAlex.
- Single-cell epigenomics of colorectal cancer.Experimental & molecular medicine · 2026Review
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- Improving Long-Read Somatic Structural Variant Calling with Pangenome and De Novo Personal Genome Assembly.Cancer research communications · 2026Article
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- Loss of CYLD on Chromosome 16q Impairs Homologous Recombination and Genomic Stability Through TIRR Degradation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Ionizing Radiation and Ultraviolet Light Irradiation-Associated DNA Damage Increasing Genomic Instability Risk.Cancer science · 2026Review
- LINE-1 insertion intermediates recombine with one another or with DNA breaks to form genome rearrangements.Nature communications · 2026Article
- Long-read sequencing of single cell-derived melanoma sublines reveals divergent and parallel genomic and epigenomic evolutionary trajectories.Nature communications · 2026Article
- Invas: an inversion-aware method for transcriptome assembly.Nature communications · 2026Article
- Clustering of inverted triplications in centromeric and subtelomeric chromosomal regions ofMicrobiology spectrum · 2026Article
- NeoCircle: pre- and post-operative circulating tumor DNA dynamics predicts survival in neoadjuvant-treated early breast cancer.EMBO molecular medicine · 2026Article
- Promoter reinforcement supports transcriptional resilience in drug-resistant cancer.Nature structural & molecular biology · 2026Article
- 53BP1-independent Shieldin-BRCA1 antagonism at replication-coupled double-strand breaks.Nature communications · 2026Article
- From fragments to full pictures: how long-read sequencing platforms are revolutionizing oncology research.Molecular biology reports · 2026Review
- Tumor Whole-Genome Sequencing for Prediction of Venous Thromboembolism in Patients With Metastasized Solid Cancer.Circulation. Genomic and precision medicine · 2026Article
- Patterns and drivers of 43,617 mosaic chromosomal alterations in blood.Nature genetics · 2026Article
- Robust discovery of mutational signatures using power posteriors.PLoS computational biology · 2026Article
494 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
16 authors at 20 institutions in 33 countries.
Yilong Li *Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, UK.
Nicola D Roberts *Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, UK.
Jeremiah A Wala *The Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Ofer Shapira *The Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Steven E SchumacherThe Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Kiran KumarThe Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Ekta KhuranaWeill Cornell Medical College, New York, NY, USA.
Sebastian WaszakEuropean Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany.
Jan O KorbelEuropean Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany.
James E HaberDepartment of Molecular Biology, Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA, USA.
Marcin ImielinskiNew York Genome Center, New York, NY, USA.
PCAWG Structural Variation Working Group
Joachim WeischenfeldtBiotech Research & Innovation Centre (BRIC), The Finsen Laboratory, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. joachim.weischenfeldt@bric.ku.dk.
Rameen BeroukhimThe Broad Institute of Harvard and MIT, Cambridge, MA, USA. rameen_beroukhim@dfci.harvard.edu.
Peter J CampbellCancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, UK. pc8@sanger.ac.uk.
PCAWG Consortium
Ontario Institute for Cancer Research · CABroad Institute · USGerman Cancer Research Center · DEWellcome Sanger Institute · GBThe University of Texas MD Anderson Cancer Center · USUniversity of Cambridge · GBUniversity of North Carolina at Chapel Hill · USThe University of Queensland · AUThe University of Sydney · AUMemorial Sloan Kettering Cancer Center · USCanada's Michael Smith Genome Sciences Centre · CAThe University of Melbourne · AUEuropean Bioinformatics Institute · GBNational Institutes of Health · USUniversitat Pompeu Fabra · ESBGI Group (China) · CNUniversity of Toronto · CARoyal Marsden NHS Foundation Trust · GBJames S. McDonnell Foundation · USYale University · US
Funding
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DIANE BODURKA · 1985 to 2026
$290.8MTraining Program in Bioinformatics and Integrative GenomicsT32HG002295 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Peter J Park · 2001 to 2026
$15.8MDNA Damage Response and Repair of a Broken ChromosomeR35GM127029 · NIGMS · BRANDEIS UNIVERSITY · PI JAMES E HABER · 2018 to 2026
$8.6MMutations Arising During DNA RepairP01GM105473 · NIGMS · BRANDEIS UNIVERSITY · PI HABER, JAMES E · 2014 to 2018
$8.6MGenetic evolution of glioblastomas during radiation and temozolomide therapyR01CA188228 · NCI · DANA-FARBER CANCER INST · PI BEROUKHIM, RAMEEN, CHAKRAVARTI, ARNAB · 2015 to 2025
$6.9MANALYSIS OF BRCA1 RECOMBINATION FUNCTIONSR01CA095175 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SCULLY, RALPH · 2002 to 2021
$4.9MPredicting the functional impact of non-coding mutations using patient-specific gene regulatory networksR01CA218668 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI EKTA KHURANA, Neville Sanjana · 2018 to 2026
$4.7MCharacterizing TP53 and PPM1D mutations as resistance drivers to radiation therapy in Diffuse Intrinsic Pontine GliomasR01CA219943 · NCI · BROAD INSTITUTE, INC. · PI BEROUKHIM, RAMEEN, LIGON, KEITH LLOYD · 2017 to 2021
$2.5MFANCM in repair of stalled replication forksR01CA217991 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SCULLY, RALPH · 2017 to 2021
$2.0MNCI NIH HHS P30 CA016672NCI NIH HHS R01 CA095175NCI NIH HHS R01 CA188228NCI NIH HHS R01 CA217991NCI NIH HHS R01 CA218668NCI NIH HHS R01 CA219943NHGRI NIH HHS T32 HG002295NIGMS NIH HHS P01 GM105473NIGMS NIH HHS R35 GM127029Wellcome Trust 088340Wellcome Trust 206194Wellcome Trust WT088340MA
Abstract
A key mutational process in cancer is structural variation, in which rearrangements delete, amplify or reorder genomic segments that range in size from kilobases to whole chromosomes
Indexed as
Genetic VariationGene RearrangementGenome, HumanGenomicsHumansMutagenesis, InsertionalNeoplasmsTelomeraseTelomeraseTERT protein, human
Identifiers
What Socratic holds
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.