ArticleNature2020
The evolutionary history of 2,658 cancers.
Erratum issuedOpen access · hybridAbstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 633 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
633citing papers in PubMed, 1 pooled it
63.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
633 citing papers in PubMed, 1 synthesis or guideline pooled it, 1,103 citations in OpenAlex.
- A meta-analysis identifies driver genes and characterizes the molecular epidemiology of colorectal cancer.Scientific reports · 2026Pooled it
- Trial
- Income Volatility and Risk of All-Cause Mortality and Cause-Specific Hospitalization Among Adults With Depression: A Nationwide Cohort Study.Journal of Korean medical science · 2026Article
- Somatic mosaicism in the brain: linking development, ageing and neurodegeneration.Nature reviews. Neurology · 2026Review
- A guide to understanding tumour evolution through the lens of population genetics.Nature reviews. Cancer · 2026Review
- Article
- Estimating the carcinogenesis timelines in early-onset versus late-onset cancers and changes across birth cohorts.Science advances · 2026Article
- Article
- Article
- Prevalence and chronology of colibactin-associated mutational processes and their microbiome spectra in Japanese colorectal cancer.Nature genetics · 2026Article
- Article
- Deconvolution of evolutionary architecture unmasks a high-risk, subclonal-rich subtype in treatment-naive small cell lung cancer.Journal of thoracic disease · 2026Article
- Clonal evolution from primary to locally recurrent rectal cancer reveals recurrence-acquired potentially actionable alterations in treatment-naïve tumors.Journal of gastroenterology · 2026Article
- Biallelic loss of RB1 in hepatocellular carcinoma as synthetic lethal target for artificial intelligence-guided therapy.Signal transduction and targeted therapy · 2026Article
- Identification and validation of a previously missed mutational signature in colorectal cancer.Nature communications · 2026Article
- Agent-Based Simulations of Lung Tumor Evolution Suggest That Ongoing Cell Competition Drives Realistic Clonal Expansions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Putative glioblastoma origin-like cells in the subventricular zone: isolation and characterization.Experimental & molecular medicine · 2026Article
- Article
- No increased risk of cancer death after endovascular aortic repair in a nationwide population-based cohort study.The British journal of surgery · 2026Article
- VariantMedium: sensitive and generalizable somatic point mutation calling with 3D DenseNets trained and evaluated on experimental data.Genome medicine · 2026Article
573 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
48 authors at 20 institutions in 34 countries.
Moritz Gerstung *European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Cambridge, UK. moritz.gerstung@ebi.ac.uk.
Clemency Jolly *The Francis Crick Institute, London, UK.
Ignaty Leshchiner *Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Stefan C Dentro *Wellcome Sanger Institute, Cambridge, UK.
Santiago Gonzalez *European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Cambridge, UK.
Daniel RosebrockBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Thomas J MitchellWellcome Sanger Institute, Cambridge, UK.
Yulia RubanovaUniversity of Toronto, Toronto, Ontario, Canada.
Pavana AnurMolecular and Medical Genetics, Oregon Health & Science University, Portland, OR, USA.
Kaixian YuThe University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Maxime TarabichiWellcome Sanger Institute, Cambridge, UK.
Amit DeshwarUniversity of Toronto, Toronto, Ontario, Canada.
Jeff WintersingerUniversity of Toronto, Toronto, Ontario, Canada.
Kortine KleinheinzGerman Cancer Research Center (DKFZ), Heidelberg, Germany.
Ignacio Vázquez-GarcíaWellcome Sanger Institute, Cambridge, UK.
Kerstin HaaseThe Francis Crick Institute, London, UK.
Lara JermanEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Cambridge, UK.
Subhajit SenguptaNorthShore University HealthSystem, Evanston, IL, USA.
Geoff MacintyreCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
Salem MalikicSimon Fraser University, Burnaby, British Columbia, Canada.
Nilgun DonmezSimon Fraser University, Burnaby, British Columbia, Canada.
Dimitri G LivitzBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Marek CmeroUniversity of Melbourne, Melbourne, Victoria, Australia.
Jonas DemeulemeesterThe Francis Crick Institute, London, UK.
Steven SchumacherBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Yu FanThe University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Xiaotong YaoWeill Cornell Medicine, New York, NY, USA.
Juhee LeeUniversity of California Santa Cruz, Santa Cruz, CA, USA.
Matthias SchlesnerGerman Cancer Research Center (DKFZ), Heidelberg, Germany.
Paul C BoutrosUniversity of Toronto, Toronto, Ontario, Canada.
David D BowtellPeter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Hongtu ZhuThe University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Gad GetzBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Marcin ImielinskiWeill Cornell Medicine, New York, NY, USA.
Rameen BeroukhimBroad Institute of MIT and Harvard, Cambridge, MA, USA.
S Cenk SahinalpVancouver Prostate Centre, Vancouver, British Columbia, Canada.
Yuan JiNorthShore University HealthSystem, Evanston, IL, USA.
Martin PeiferUniversity of Cologne, Cologne, Germany.
Florian MarkowetzCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
Ville MustonenUniversity of Helsinki, Helsinki, Finland.
Ke YuanCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
Wenyi WangThe University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Quaid D MorrisUniversity of Toronto, Toronto, Ontario, Canada.
PCAWG Evolution & Heterogeneity Working Group
Paul T SpellmanMolecular and Medical Genetics, Oregon Health & Science University, Portland, OR, USA.
David C WedgeBig Data Institute, University of Oxford, Oxford, UK.
Peter Van LooThe Francis Crick Institute, London, UK. peter.vanloo@crick.ac.uk.
PCAWG Consortium
Ontario Institute for Cancer Research · CABroad Institute · USThe University of Texas MD Anderson Cancer Center · USWellcome Sanger Institute · GBGerman Cancer Research Center · DEEuropean Bioinformatics Institute · GBUniversity of Cambridge · GBUniversity of North Carolina at Chapel Hill · USThe University of Melbourne · AUMemorial Sloan Kettering Cancer Center · USCanada's Michael Smith Genome Sciences Centre · CAUniversity of Toronto · CAThe University of Sydney · AUBGI Group (China) · CNNational Institutes of Health · USThe University of Queensland · AUThe Francis Crick Institute · GBBaylor College of Medicine · USOregon Health & Science University · USRoyal Marsden NHS Foundation Trust · GB
Funding
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8MProteomicsP01CA206978 · NCI · DANA-FARBER CANCER INST · PI WU, CATHERINE JU-YING · 2016 to 2025
$17.0MTumor evolution and intratumor heterogeneityZIABC011987 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI SAHINALP, SULEYMAN · 2020 to 2025
$6.6MTCGA Data Analysis Center at BerkeleyU24CA143799 · NCI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI SPEED, TERENCE PAUL, SPELLMAN, PAUL T. · 2009 to 2016
$4.9MGlobal Infrastructure for Collaborative High-throughput Cancer Genomics AnalysisU24CA210999 · NCI · BROAD INSTITUTE, INC. · PI GETZ, GAD A · 2016 to 2020
$4.7MStatistical Analysis of Biomedical Imaging Data in Curved SpaceR01MH086633 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI IBRAHIM, JOSEPH G · 2010 to 2018
$2.9MOHSU Center for Specialized Data Analysis as part of the GDANU24CA210957 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI DEMIR, EMEK, SPELLMAN, PAUL T. · 2016 to 2020
$2.2MBayesian models for cancer prognosis by integrating diverse types of dataR01CA132897 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI JI, YUAN, MUELLER, PETER · 2008 to 2019
$2.1MStatistical methods for genomic analysis of heterogeneous tumorsR01CA183793 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI WANG, WENYI · 2014 to 2018
$1.7MPathway and Network Integration of Cancer Genomics and Clinical DataU24CA211000 · NCI · PRINCETON UNIVERSITY · PI RAPHAEL, BENJAMIN, YEH, JEN JEN · 2016 to 2020
$1.7MCancer Research UK 15973Cancer Research UK 19274Cancer Research UK 27176Cancer Research UK 28290Medical Research Council MR/L016311Medical Research Council MR/L016311/1NCI NIH HHS 1U24CA143799NCI NIH HHS P01 CA206978NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA132897NCI NIH HHS R01 CA183793NCI NIH HHS U24 CA143799NCI NIH HHS U24 CA210957NCI NIH HHS U24 CA210999NCI NIH HHS U24 CA211000NIH HHS GM108308NIMH NIH HHS MH086633Wellcome Trust FC001202
Abstract
Cancer develops through a process of somatic evolution
Indexed as
Evolution, MolecularDNA RepairGene DosageGenes, Tumor SuppressorGenetic VariationGenome, HumanHumansMutagenesis, InsertionalNeoplasms
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.