ArticleNature2020
Analyses of non-coding somatic drivers in 2,658 cancer whole genomes.
Erratum issuedOpen access · hybridAbstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 354 papers.
0numbers the graph read from it
0cells of the map it votes in
354citing papers in PubMed
36.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
354 citing papers in PubMed, 648 citations in OpenAlex.
- Genetically engineered hypoimmunogenic iPSCs: Strategies and considerations for clinical applications.Regenerative therapy · 2026Review
- Mapping the functional dark proteome in cancer.Nature reviews. Cancer · 2026Review
- Clustered structural variant hotspots enable oncogenic addiction and plasticity in osteosarcoma.bioRxiv : the preprint server for biology · 2026Article
- YAP1 induces hepatocellular carcinoma via DNA demethylation rather than by canonical driver gene mutations.Communications biology · 2026Article
- Evolving patterns of co-mutations from tumor initiation to metastatic progression.Nature genetics · 2026Article
- Gene mutant dosage is associated with prognosis and metastatic tropism in 60,000 clinical cancer samples.Nature genetics · 2026Article
- Deciphering the genetic underlying causes of sex differences in multiple myeloma incidence and mortality.HGG advances · 2026Article
- Pathophysiology of colitis-associated colorectal cancer.Nature reviews. Gastroenterology & hepatology · 2026Review
- BCL2 promoter region mutations are an independent marker of BCL2 level in lymphoid malignancies.NPJ genomic medicine · 2026Article
- Article
- Global Geo-Pharmacogenomics: Environmental Mutational Signatures Drive Population-Level Heterogeneity in Anticancer Drug Response.Journal of xenobiotics · 2026Article
- Genomic context of mutations in MIR142 in blood cancers: summary and integrative analysis.Cellular & molecular biology letters · 2026Review
- Continuous multi-omics pathway enrichment analysis resolves hidden functional heterogeneity.Briefings in bioinformatics · 2026Article
- Single-cell profiling reveals distinct populations of tumor-associated macrophages and metastatic tumor cells in breast cancer brain metastasis.Cell death & disease · 2026Article
- Esophageal cancer: from pathogenesis to precision therapies.Signal transduction and targeted therapy · 2026Review
- Investigating the contribution of rare non-coding variants in BRCA1, BRCA2 and PALB2 to hereditary breast cancer.NPJ breast cancer · 2026Article
- Cis-regulatory and long noncoding RNA alterations in breast cancer - current insights, biomarker utility, and the critical need for functional validation.Molecular oncology · 2026Review
- Genome-wide analysis of somatic noncoding mutation patterns and mitochondrial heteroplasmic shift in type B1 and B2 thymomas.The Journal of pathology · 2026Article
- Article
- 5mC and 5hmC methylation sequencing: the power of 6-base sequencing in a multiomic era.Epigenomics · 2026Review
294 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
97 authors at 20 institutions in 33 countries.
Esther Rheinbay *The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Morten Muhlig Nielsen *Department of Molecular Medicine (MOMA), Aarhus University Hospital, Aarhus, Denmark.
Federico Abascal *Wellcome Trust Sanger Institute, Hinxton, UK.
Jeremiah A Wala *The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Ofer Shapira *The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Grace TiaoThe Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Henrik HornshøjDepartment of Molecular Medicine (MOMA), Aarhus University Hospital, Aarhus, Denmark.
Julian M HessThe Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Randi Istrup JuulDepartment of Molecular Medicine (MOMA), Aarhus University Hospital, Aarhus, Denmark.
Ziao LinThe Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Lars FeuerbachDivision of Applied Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Radhakrishnan SabarinathanInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Tobias MadsenDepartment of Molecular Medicine (MOMA), Aarhus University Hospital, Aarhus, Denmark.
Jaegil KimThe Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Loris MularoniInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Shimin ShuaiComputational Biology Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
Andrés LanzósDepartment for BioMedical Research, University of Bern, Bern, Switzerland.
Carl HerrmannDivision of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Yosef E MaruvkaThe Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Ciyue ShenDepartment of Cell Biology, Harvard Medical School, Boston, MA, USA.
Samirkumar B AminDepartment of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Pratiti BandopadhayayThe Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Johanna BertlDepartment of Molecular Medicine (MOMA), Aarhus University Hospital, Aarhus, Denmark.
Keith A BoroevichLaboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
John BusanovichThe Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Joana Carlevaro-FitaDepartment for BioMedical Research, University of Bern, Bern, Switzerland.
Dimple ChakravartyDepartment of Genitourinary Medical Oncology - Research, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Calvin Wing Yiu ChanDivision of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
David CraftDepartment of Radiation Oncology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.
Priyanka DhingraDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
Klev DiamantiScience for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden.
Nuno A FonsecaEuropean Bioinformatics Institute, European Molecular Biology Laboratory, Hinxton, UK.
Abel Gonzalez-PerezInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Qianyun GuoBioinformatics Research Centre (BiRC), Aarhus University, Aarhus, Denmark.
Mark P HamiltonDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Nicholas J HaradhvalaThe Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Chen HongDivision of Applied Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Keren IsaevComputational Biology Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
Todd A JohnsonLaboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Malene JuulDepartment of Molecular Medicine (MOMA), Aarhus University Hospital, Aarhus, Denmark.
Andre KahlesDivision of Computational Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Abdullah KahramanInstitute of Molecular Life Sciences and Swiss Institute of Bioinformatics, University of Zurich, Zurich, Switzerland.
Youngwook KimSamsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Jan KomorowskiScience for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden.
Kiran KumarThe Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Sushant KumarProgram in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA.
Donghoon LeeProgram in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA.
Kjong-Van LehmannDivision of Computational Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Yilong LiSBGD Inc, Cambridge, MA, USA.
Eric Minwei LiuDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
Lucas LochovskyDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA.
Keunchil ParkSamsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Oriol PichInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Nicola D RobertsDepartment of Haematology, University of Cambridge, Cambridge, UK.
Gordon SaksenaThe Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Steven E SchumacherThe Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Nikos SidiropoulosBiotech Research & Innovation Centre (BRIC), The Finsen Laboratory, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Lina SieverlingDivision of Applied Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Nasa Sinnott-ArmstrongDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Chip StewartThe Broad Institute of MIT and Harvard, Cambridge, MA, USA.
David TamboreroInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Jose M C TubioDepartment of Zoology, Genetics and Physical Anthropology, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
Husen M UmerScience for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden.
Liis Uusküla-ReimandGenetics and Genome Biology Program, SickKids Research Institute, Toronto, Ontario, Canada.
Claes WadeliusScience for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Lina WadiComputational Biology Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
Xiaotong YaoNew York Genome Center, New York, NY, USA.
Cheng-Zhong ZhangDepartment of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Jing ZhangProgram in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA.
James E HaberDepartment of Biology and Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA, USA.
Asger HobolthBioinformatics Research Centre (BiRC), Aarhus University, Aarhus, Denmark.
Marcin ImielinskiNew York Genome Center, New York, NY, USA.
Manolis KellisThe Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Michael S LawrenceThe Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Christian von MeringInstitute of Molecular Life Sciences and Swiss Institute of Bioinformatics, University of Zurich, Zurich, Switzerland.
Hidewaki NakagawaLaboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Tokyo, Japan.
Benjamin J RaphaelDepartment of Computer Science, Princeton University, Princeton, NJ, USA.
Mark A RubinDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
Chris SanderDepartment of Cell Biology, Harvard Medical School, Boston, MA, USA.
Lincoln D SteinComputational Biology Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
Joshua M StuartCenter for Biomolecular Science and Engineering, University of California at Santa Cruz, Santa Cruz, CA, USA.
Tatsuhiko TsunodaLaboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
David A WheelerHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
Rory JohnsonDepartment for BioMedical Research, University of Bern, Bern, Switzerland.
Jüri ReimandComputational Biology Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
Mark GersteinProgram in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA.
Ekta KhuranaDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
Peter J CampbellWellcome Trust Sanger Institute, Hinxton, UK.
Núria López-BigasInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.
PCAWG Drivers and Functional Interpretation Working Group
PCAWG Structural Variation Working Group
Joachim WeischenfeldtBiotech Research & Innovation Centre (BRIC), The Finsen Laboratory, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. joachim.weischenfeldt@bric.ku.dk.
Rameen BeroukhimThe Broad Institute of MIT and Harvard, Cambridge, MA, USA. rameen@broadinstitute.org.
Iñigo MartincorenaWellcome Trust Sanger Institute, Hinxton, UK. im3@sanger.ac.uk.
Jakob Skou PedersenDepartment of Molecular Medicine (MOMA), Aarhus University Hospital, Aarhus, Denmark. jakob.skou@clin.au.dk.
Gad GetzThe Broad Institute of MIT and Harvard, Cambridge, MA, USA. gadgetz@broadinstitute.org.
PCAWG Consortium
Broad Institute · USOntario Institute for Cancer Research · CAWellcome Sanger Institute · GBGerman Cancer Research Center · DEUniversity of Cambridge · GBThe University of Texas MD Anderson Cancer Center · USMemorial Sloan Kettering Cancer Center · USYale University · USUniversity of North Carolina at Chapel Hill · USEuropean Bioinformatics Institute · GBHarvard University · USBaylor College of Medicine · USThe University of Melbourne · AUAarhus University Hospital · DKCanada's Michael Smith Genome Sciences Centre · CAThe University of Sydney · AUNational Institutes of Health · USUniversitat Pompeu Fabra · ESBGI Group (China) · CNThe University of Queensland · AU
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MTumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007205 · NIGMS · YALE UNIVERSITY · PI KAZMIERCZAK, BARBARA I · 1985 to 2019
$42.9MThe Cancer Genome Atlas Data Analysis CenterU24CA143845 · NCI · BROAD INSTITUTE, INC. · PI CHIN, LYNDA, GETZ, GAD A · 2009 to 2016
$16.0MTraining Program in Bioinformatics and Integrative GenomicsT32HG002295 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Peter J Park · 2001 to 2026
$15.8MMOLECULAR BIOPHYSICS TRAINING GRANTT32GM008313 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI MURTHY, VENKATESH N · 1989 to 2023
$14.6MThe Cell-Of-Origin of Human CancersU54CA143798 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI MICHOR, FRANZISKA · 2009 to 2014
$11.2MDNA Damage Response and Repair of a Broken ChromosomeR35GM127029 · NIGMS · BRANDEIS UNIVERSITY · PI JAMES E HABER · 2018 to 2026
$8.6MGenetic evolution of glioblastomas during radiation and temozolomide therapyR01CA188228 · NCI · DANA-FARBER CANCER INST · PI BEROUKHIM, RAMEEN, CHAKRAVARTI, ARNAB · 2015 to 2025
$6.9MANALYSIS OF BRCA1 RECOMBINATION FUNCTIONSR01CA095175 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SCULLY, RALPH · 2002 to 2021
$4.9MPredicting the functional impact of non-coding mutations using patient-specific gene regulatory networksR01CA218668 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI EKTA KHURANA, Neville Sanjana · 2018 to 2026
$4.7MGlobal Infrastructure for Collaborative High-throughput Cancer Genomics AnalysisU24CA210999 · NCI · BROAD INSTITUTE, INC. · PI GETZ, GAD A · 2016 to 2020
$4.7MCancer Research UK 21777NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA095175NCI NIH HHS R01 CA188228NCI NIH HHS R01 CA215489NCI NIH HHS R01 CA217991NCI NIH HHS R01 CA218668NCI NIH HHS R01 CA219943NCI NIH HHS U24 CA143845NCI NIH HHS U24 CA210990NCI NIH HHS U24 CA210999NCI NIH HHS U24 CA211000NCI NIH HHS U54 CA143798NHGRI NIH HHS R01 HG007069NHGRI NIH HHS T32 HG002295NIGMS NIH HHS R35 GM127029NIGMS NIH HHS T32 GM007205NIGMS NIH HHS T32 GM008313
Abstract
The discovery of drivers of cancer has traditionally focused on protein-coding genes
Indexed as
Databases, GeneticDNA BreaksGene Expression Regulation, NeoplasticGenome, HumanGenome-Wide Association StudyHumansINDEL MutationMutationNeoplasms
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.