ArticleNature2020
Genomic basis for RNA alterations in cancer.
Erratum issuedOpen access · hybridAbstract readDataset
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 259 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
259citing papers in PubMed, 1 pooled it
25.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
259 citing papers in PubMed, 1 synthesis or guideline pooled it, 419 citations in OpenAlex.
- Effectiveness of Artificial Intelligence for Personalized Medicine in Neoplasms: A Systematic Review.BioMed research international · 2022Pooled it
- RHOA Deletion Downregulates CD19 and Promotes Dysfunctional Immune Microenvironments in CAR-T Resistant Large B-cell Lymphomas.Blood cancer discovery · 2026Article
- Condensates and cell states: A new paradigm for understanding tumor biology.Biophysical journal · 2026Review
- Cancer-associated fusion transcripts: mechanisms, functional roles, and clinical implications.Clinical and experimental medicine · 2026Review
- Mechanisms of LARP7 in regulating the progression of non-small cell lung cancer.Journal of thoracic disease · 2026Article
- Integrating DNA Mutations and RNA Expression of Cancer Driver Genes in Asian Rare Cancers: A Pan-Cancer Analysis.JCO precision oncology · 2026Article
- Out-of-frame CBX3::ALK fusion drives ALK activation and therapy response.Cell reports. Medicine · 2026Article
- Confounding factors in assessing the enriched expression of somatic mutant alleles in bulk tumor samples.Genome research · 2026Article
- Comparison of gene fusion detection algorithms reveals frequently overlooked driver fusions in hematologic malignancies.NPJ precision oncology · 2026Article
- Landscape of Allele-Specific Expression in Prostate Cancer Reveals Recurrent, Stage-Specific Events in AR Signaling and Resistance Pathways.Molecular cancer research : MCR · 2026Article
- IFDlong: a model-based isoform and fusion detector for accurate annotation and quantification of long-read RNA-seq data.Genome biology · 2026Article
- A Prognostic Signature for Lung Adenocarcinoma in Patients Who Have Never Smoked.Cancer discovery · 2026Article
- EMC3 as a Novel Biomarker and Driver of PI3K/AKT/mTOR Signaling in Hepatocellular Carcinoma Progression.Annals of surgical oncology · 2026Article
- Article
- A guide to transcriptomic deconvolution in cancer.Nature reviews. Cancer · 2026Review
- Systematic fusion transcript discovery in mantle cell lymphoma using long-read sequencing.bioRxiv : the preprint server for biology · 2026Article
- RNA-coupled CRISPR screens reveal ZNF207 as a regulator of LMNA aberrant splicing in progeria.Molecular cell · 2026Article
- MODCAN: driver gene identification based on multi-omics features and differential co-association networks for tumor subtypes.BMC bioinformatics · 2026Article
- The Extrachromosomal DNA Fusion Factory: Extrachromosomal Genesis of Oncogenic Fusion Transcripts.Research (Washington, D.C.) · 2026Article
- Differences in the expression profiles of m6A-related genes and the prognostic role in immunotherapy for lung adenocarcinoma patients.Frontiers in oncology · 2026Article
199 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
53 authors at 20 institutions in 33 countries.
PCAWG Transcriptome Core Group
Claudia Calabrese *European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.
Natalie R Davidson *ETH Zurich, Zurich, Switzerland.
Deniz Demircioğlu *National University of Singapore, Singapore, Singapore.
Nuno A Fonseca *European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.
Yao He *Peking University, Beijing, China.
André Kahles *ETH Zurich, Zurich, Switzerland.
Kjong-Van Lehmann *ETH Zurich, Zurich, Switzerland.
Fenglin Liu *Peking University, Beijing, China.
Yuichi Shiraishi *The University of Tokyo, Minato-ku, Japan.
Cameron M Soulette *University of California, Santa Cruz, Santa Cruz, CA, USA.
Lara Urban *European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.
Liliana GregerEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.
Siliang LiBGI-Shenzhen, Shenzhen, China.
Dongbing LiuBGI-Shenzhen, Shenzhen, China.
Marc D PerryOntario Institute for Cancer Research, Toronto, Ontario, Canada.
Qian XiangOntario Institute for Cancer Research, Toronto, Ontario, Canada.
Fan ZhangPeking University, Beijing, China.
Junjun ZhangOntario Institute for Cancer Research, Toronto, Ontario, Canada.
Peter BaileyUniversity of Glasgow, Glasgow, UK.
Serap ErkekEuropean Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany.
Katherine A HoadleyThe University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Yong HouBGI-Shenzhen, Shenzhen, China.
Matthew R HuskaBerlin Institute for Medical Systems Biology, Max Delbruck Center for Molecular Medicine, Berlin, Germany.
Helena KilpinenUniversity College London, London, UK.
Jan O KorbelEuropean Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany.
Maximillian G MarinUniversity of California, Santa Cruz, Santa Cruz, CA, USA.
Julia MarkowskiBerlin Institute for Medical Systems Biology, Max Delbruck Center for Molecular Medicine, Berlin, Germany.
Tannistha NandiGenome Institute of Singapore, Singapore, Singapore.
Qiang Pan-HammarströmBGI-Shenzhen, Shenzhen, China.
Chandra Sekhar PedamalluBroad Institute, Cambridge, MA, USA.
Reiner SiebertUlm University and Ulm University Medical Center, Ulm, Germany.
Stefan G StarkETH Zurich, Zurich, Switzerland.
Hong SuBGI-Shenzhen, Shenzhen, China.
Patrick TanGenome Institute of Singapore, Singapore, Singapore.
Sebastian M WaszakEuropean Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany.
Christina YungOntario Institute for Cancer Research, Toronto, Ontario, Canada.
Shida ZhuBGI-Shenzhen, Shenzhen, China.
Philip AwadallaOntario Institute for Cancer Research, Toronto, Ontario, Canada.
Chad J CreightonBaylor College of Medicine, Houston, TX, USA.
Matthew MeyersonBroad Institute, Cambridge, MA, USA.
B F Francis OuelletteUniversity of Toronto, Toronto, Ontario, Canada.
Kui WuBGI-Shenzhen, Shenzhen, China.
Huanming YangBGI-Shenzhen, Shenzhen, China.
PCAWG Transcriptome Working Group
Alvis BrazmaEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK. brazma@ebi.ac.uk.
Angela N BrooksUniversity of California, Santa Cruz, Santa Cruz, CA, USA. anbrooks@ucsc.edu.
Jonathan GökeGenome Institute of Singapore, Singapore, Singapore.
Gunnar RätschETH Zurich, Zurich, Switzerland. raetsch@inf.ethz.ch.
Roland F SchwarzEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.
Oliver StegleEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.
Zemin ZhangPeking University, Beijing, China.
PCAWG Consortium
Ontario Institute for Cancer Research · CABroad Institute · USGerman Cancer Research Center · DEWellcome Sanger Institute · GBEuropean Bioinformatics Institute · GBBGI Group (China) · CNUniversity of North Carolina at Chapel Hill · USThe University of Sydney · AUMemorial Sloan Kettering Cancer Center · USThe University of Texas MD Anderson Cancer Center · USCanada's Michael Smith Genome Sciences Centre · CAThe University of Queensland · AUNational Institutes of Health · USThe University of Melbourne · AUUniversity of Cambridge · GBUniversitat Pompeu Fabra · ESUniversity of California, Santa Cruz · USUniversity of Toronto · CAPeking University · CNSIB Swiss Institute of Bioinformatics · CH
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MTumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8MUNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3MUNIVERSITY OF CALIFORNIA, SANTA CRUZ IMSD PROGRAMR25GM058903 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI JURICA, MELISSA S · 1999 to 2019
$12.2MTraining Program/Molecular/Cell/Developmental BiologyT32GM008646 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI STROME, SUSAN · 1999 to 2018
$3.7MEuropean Research CouncilMedical Research Council MR/L016311/1NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA016672NIEHS NIH HHS P30 ES010126NIGMS NIH HHS R25 GM058903NIGMS NIH HHS T32 GM008646NIH HHS 2R25GM058903
Abstract
Transcript alterations often result from somatic changes in cancer genomes
Indexed as
Gene Expression Regulation, NeoplasticDNA Copy Number VariationsDNA, NeoplasmGenome, HumanGenomicsHumansNeoplasmsRNATranscriptomeDNA, NeoplasmRNA
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.