Evidence map›Paper›PMID 32025796›Full record

ArticleInternational archives of occupational and environmental health2020

Occupational livestock or animal dust exposure and offspring cancer risk in Denmark, 1968-2016.

Clinton Hall, Johnni Hansen, Ondine S von Ehrenstein, Di He, Jørn Olsen, Beate Ritz, Julia E Heck

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International archives of occupational and environmental health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Childhood cancer risk in offspring of mothers occupationally exposed to hydrocarbon solvents.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2026
    Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Clinton HallDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA.
Johnni HansenDanish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark.
Ondine S von EhrensteinDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA.
Di HeDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA.
Jørn OlsenDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA.
Beate RitzDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA.
Julia E HeckDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA. jeheck@ucla.edu.
University of California, Los Angeles · USDanish Cancer Society · DK

Funding

Southern California Education and Research Center T42OH008412 · OH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JONES, RACHAEL MARY · 2005 to 2025
$28.1M
Maternal comorbidities, prescription drug use in pregnancy and childhood cancerR21CA175959 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HECK, JULIA · 2014 to 2015
$323k
Parental Occupation and Childhood CancersR03ES021643 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HECK, JULIA · 2012 to 2013
$152k
ACL HHS T42OH008412Alex's Lemonade Stand Foundation for Childhood Cancer 17-01882NCI NIH HHS R21 CA175959NIEHS NIH HHS R03 ES021643NIH HHS R03ES021643NIH HHS R21CA175959NIOSH CDC HHS T42OH008412
6 · The paper itself

Abstract

objectiveTo examine associations with occupational livestock or other animal dust exposure and offspring cancer risk.

methodsIn this population-based case-control study of Danish children aged < 17 years old, 5078 childhood cancer cases diagnosed 1968-2016 were matched to cancer-free controls by birth year and sex (n = 123,228). Occupational livestock or animal dust exposure was identified using a job-exposure matrix. We employed multivariable conditional logistic regression models to estimate associations with offspring cancer for births 1968-2016 and 1989-2016, with the latter timeframe reflecting a period of presumed higher exposure due to changes in Danish farming practices. Sensitivity analyses considered place of birth (urban areas vs. rural areas and small towns).

resultsFor births 1968-2016, paternal exposure from offspring birth to cancer diagnosis was associated with central nervous system tumors (adjusted odds ratio [OR] = 1.30, 95% confidence interval [CI] 1.04-1.63) and germ cell tumors (OR = 1.82, 95% CI 1.05-3.27), while maternal pregnancy exposure was associated with astrocytoma (OR = 1.89, 95% CI 1.00-3.57). For births 1989-2016, paternal exposure from offspring birth to cancer diagnosis was negatively associated with acute lymphoid leukemia (OR = 0.58, 95% CI 0.33-1.00). For births in rural areas only, maternal exposure from offspring birth to cancer diagnosis was positively associated with acute myeloid leukemia (OR = 2.16, 95% CI 1.09-4.29).

conclusionsThis study suggests that paternal occupational animal exposure is associated with offspring germ cell tumors, and maternal pregnancy exposure with astrocytomas. Our results are mixed with respect to leukemia subtypes.

Indexed as

DustLivestockAdolescentAdultAgedAnimal HusbandryAnimalsCase-Control StudiesChildChild, PreschoolDenmarkFemaleHumansInfantMaleMaternal ExposureDustParticulate MatterCentral nervous system tumorChildhood cancerGerm cell tumorJob-exposure matrixLeukemia

Identifiers

PMID32025796
PMCPMC7261625
OpenAlexW3004881102

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.