Evidence map›Paper›PMID 32029441›Full record

ArticleeNeuro

Parvalbumin Interneuron Dysfunction in a Thalamo-Prefrontal Cortical Circuit in

Kristen Delevich, Hanna Jaaro-Peled, Mario Penzo, Akira Sawa, Bo Li

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 24 citations in OpenAlex.

  1. Dynamic alterations in the central glutamatergic status following food and glucose intake:Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Prefrontal Interneurons: Populations, Pathways, and Plasticity Supporting Typical and Disordered Cognition in Rodent Models.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Review
  12. eLife · 2022
    Article
  13. Article
  14. Review
  15. The Contribution of Thalamic Nuclei in Salience Processing.Frontiers in behavioral neuroscience · 2021
    Review
  16. Parvalbumin interneuron vulnerability and brain disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021
    Review
  17. Review
  18. Article
  19. The Parvalbumin Hypothesis of Autism Spectrum Disorder.Frontiers in cellular neuroscience · 2020
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Kristen DelevichCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724 delevich@berkeley.edu.
Hanna Jaaro-PeledDepartment of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287.ORCID 0000-0002-8950-391X
Mario PenzoNational Institute of Mental Health, Bethesda, MD 20892.
Akira SawaDepartment of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287.
Bo LiCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724.ORCID 0000-0002-0154-3088
Cold Spring Harbor Laboratory · USJohns Hopkins University · USNational Institute of Mental Health · US

Funding

Project 3P50MH094268 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SAWA, AKIRA · 2011 to 2020
$19.9M
Dissecting the stress circuits of the paraventricular nucleus of the thalamusZIAMH002950 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PENZO, MARIO · 2016 to 2025
$17.5M
The basal ganglia–habenula circuitry in reward processingR01MH108924 · NIMH · COLD SPRING HARBOR LABORATORY · PI Jessica Tollkuhn · 2015 to 2026
$6.8M
The central amygdala circuits in motivated behaviorsR01MH101214 · NIMH · COLD SPRING HARBOR LABORATORY · PI VAN AELST, LINDA · 2014 to 2024
$6.3M
CSHL Watson School of Biological SciencesT32GM065094 · NIGMS · COLD SPRING HARBOR LABORATORY · PI GANN, ALEXANDER · 2002 to 2021
$4.8M
DISC1-dependent defects in neural fate, corticogenesis and cognition in psychosisR01MH105660 · NIMH · JOHNS HOPKINS UNIVERSITY · PI ISHIZUKA, KOKO, SAWA, AKIRA · 2014 to 2018
$2.8M
NIGMS NIH HHS T32 GM065094NIMH NIH HHS P50 MH094268NIMH NIH HHS R01 MH101214NIMH NIH HHS R01 MH105660NIMH NIH HHS R01 MH108924
6 · The paper itself

Abstract

Altered cortical excitation-inhibition (E-I) balance resulting from abnormal parvalbumin interneuron (PV IN) function is a proposed pathophysiological mechanism of schizophrenia and other major psychiatric disorders. Preclinical studies have indicated that

Indexed as

InterneuronsParvalbuminsAnimalsMiceMice, Inbred C57BLNerve Tissue ProteinsPrefrontal CortexSomatostatinDisc1 protein, mouseNerve Tissue ProteinsParvalbuminsSomatostatindisrupted-in-schizophrenia-1feedforward inhibitionmediodorsal thalamusparvalbumin interneuronsprefrontal cortex

Identifiers

PMID32029441
PMCPMC7054897
OpenAlexW3004599913

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.