Evidence map›Paper›PMID 32032546›Full record

ArticleDevelopmental cell2020

YAP Regulates Hematopoietic Stem Cell Formation in Response to the Biomechanical Forces of Blood Flow.

Vanessa Lundin, Wade W Sugden, Lindsay N Theodore, Patricia M Sousa, Areum Han, Stephanie Chou, Paul J Wrighton, Andrew G Cox, Donald E Ingber, Wolfram Goessling and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
8.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 118 citations in OpenAlex.

  1. Article
  2. Yorkie/YAP Interactors: Fine-Tuning the Hippo Pathway Output.Cold Spring Harbor perspectives in biology · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Mechanometabolism instructs hematopoietic stem cell specification.The Journal of experimental medicine · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Multimodal analysis ofbioRxiv : the preprint server for biology · 2025
    Article
  17. Review
  18. Article
  19. Review
  20. Review

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Vanessa LundinStem Cell Program, Division of Pediatric Hematology and Oncology, Boston Children's Hospital, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.
Wade W SugdenStem Cell Program, Division of Pediatric Hematology and Oncology, Boston Children's Hospital, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
Lindsay N TheodoreStem Cell Program, Division of Pediatric Hematology and Oncology, Boston Children's Hospital, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
Patricia M SousaStem Cell Program, Division of Pediatric Hematology and Oncology, Boston Children's Hospital, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
Areum HanStem Cell Program, Division of Pediatric Hematology and Oncology, Boston Children's Hospital, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
Stephanie ChouStem Cell Program, Division of Pediatric Hematology and Oncology, Boston Children's Hospital, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
Paul J WrightonHarvard Stem Cell Institute, Cambridge, MA 02138, USA; Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Andrew G CoxHarvard Stem Cell Institute, Cambridge, MA 02138, USA; Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Donald E IngberWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA; Vascular Biology Program, Department of Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA; Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.
Wolfram GoesslingHarvard Stem Cell Institute, Cambridge, MA 02138, USA; Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Dana-Farber Cancer Institute, Boston, MA 02115, USA; Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, Boston, MA 02115, USA.
George Q DaleyStem Cell Program, Division of Pediatric Hematology and Oncology, Boston Children's Hospital, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Trista E NorthStem Cell Program, Division of Pediatric Hematology and Oncology, Boston Children's Hospital, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address: trista.north@childrens.harvard.edu.
Boston Children's Hospital · USBrigham and Women's Hospital · US

Funding

Customized stem cells for clinical application in blood disordersR24DK092760 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI COLLINS, JAMES J, DALEY, GEORGE Q · 2011 to 2018
$10.7M
TRANSFUSION BIOLOGY AND MEDICINET32HL066987 · NHLBI · CHILDREN'S HOSPITAL BOSTON · PI JOHN P MANIS · 2001 to 2026
$10.2M
Stem cells for therapeutics discovery in genetic blood disordersU01HL134812 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI DALEY, GEORGE Q, LIPTON, JEFFREY M · 2016 to 2022
$8.3M
Metabolic Regulation of Liver GrowthR01DK105198 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI GOESSLING, WOLFRAM · 2016 to 2020
$2.7M
Metabolic regulation of hematopoietic stem cell specification and functionR01DK098241 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI NORTH, TRISTA E. · 2014 to 2018
$2.0M
The role of mechanical signaling in alcoholic liver disease and hepatocellular carcinomaF32AA025271 · NIAAA · BRIGHAM AND WOMEN'S HOSPITAL · PI WRIGHTON, PAUL J. · 2016 to 2018
$174k
Mechanisms of Flow-Mediated YAP Activation in Hematopoietic Stem CellsF32DK122715 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI SUGDEN, WADE WILLIAM · 2019 to 2019
$62k
The Role of Inflammation and Inflammatory Mediators in HematopoiesisF31HL132410 · NHLBI · HARVARD MEDICAL SCHOOL · PI THEODORE, LINDSAY NICOLE · 2017 to 2018
$39k
NHLBI NIH HHS F31 HL132410NHLBI NIH HHS T32 HL066987NHLBI NIH HHS U01 HL134812NIAAA NIH HHS F32 AA025271NIDDK NIH HHS F32 DK122715NIDDK NIH HHS R01 DK098241NIDDK NIH HHS R01 DK105198NIDDK NIH HHS R24 DK092760
6 · The paper itself

Abstract

Hematopoietic stem and progenitor cells (HSPCs), first specified from hemogenic endothelium (HE) in the ventral dorsal aorta (VDA), support lifelong hematopoiesis. Their de novo production promises significant therapeutic value; however, current in vitro approaches cannot efficiently generate multipotent long-lived HSPCs. Presuming this reflects a lack of extrinsic cues normally impacting the VDA, we devised a human dorsal aorta-on-a-chip platform that identified Yes-activated protein (YAP) as a cyclic stretch-induced regulator of HSPC formation. In the zebrafish VDA, inducible Yap overexpression significantly increased runx1 expression in vivo and the number of CD41

Indexed as

HematopoiesisMechanotransduction, CellularAnimalsAortaCell Cycle ProteinsCell DifferentiationCore Binding Factor Alpha 2 SubunitEmbryo, NonmammalianEndothelium, VascularHematopoietic Stem CellsHemodynamicsHumansInduced Pluripotent Stem Cellsrho GTP-Binding ProteinsTranscription FactorsZebrafishCell Cycle ProteinsCore Binding Factor Alpha 2 Subunitrho GTP-Binding ProteinsRUNX1 protein, humanTranscription FactorsYY1AP1 protein, humanblood flowcyclic stretchendothelial-to-hematopoietic transitionhematopoietic stem cellshemogenic endotheliumorgan-on-a-chipRho-GTPaseRUNX1YAPzebrafish

Identifiers

PMID32032546
PMCPMC7398148
OpenAlexW3005260029

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.