Evidence map›Paper›PMID 32033331›Full record

ArticleNanomaterials (Basel, Switzerland)2020

Investigation of the Electrical Properties of Microtubule Ensembles under Cell-Like Conditions.

Aarat P Kalra, Sahil D Patel, Asadullah F Bhuiyan, Jordane Preto, Kyle G Scheuer, Usman Mohammed, John D Lewis, Vahid Rezania, Karthik Shankar, Jack A Tuszynski

Abstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Virus-Induced Membrane Fusion in Neurodegenerative Disorders.Frontiers in cellular and infection microbiology · 2022
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Aarat P KalraDepartment of Physics, University of Alberta, 11335 Saskatchewan Dr NW, Edmonton, Alberta T6G 2M9, Canada.
Sahil D PatelDepartment of Electrical and Computer Engineering, University of Alberta, 9107-116 St, Edmonton, Alberta T6G 2V4, Canada .
Asadullah F BhuiyanDepartment of Electrical and Computer Engineering, University of Alberta, 9107-116 St, Edmonton, Alberta T6G 2V4, Canada .
Jordane PretoDepartment of Physics, University of Alberta, 11335 Saskatchewan Dr NW, Edmonton, Alberta T6G 2M9, Canada.
Kyle G ScheuerDepartment of Electrical and Computer Engineering, University of Alberta, 9107-116 St, Edmonton, Alberta T6G 2V4, Canada .
Usman MohammedDepartment of Physical Sciences, MacEwan University, Edmonton, Alberta, T5J 4S2, Canada.
John D LewisDepartment of Oncology, University of Alberta, Edmonton, Alberta, T6G 1Z2, Canada.
Vahid RezaniaDepartment of Physical Sciences, MacEwan University, Edmonton, Alberta, T5J 4S2, Canada.
Karthik ShankarDepartment of Electrical and Computer Engineering, University of Alberta, 9107-116 St, Edmonton, Alberta T6G 2V4, Canada .
Jack A TuszynskiDepartment of Physics, University of Alberta, 11335 Saskatchewan Dr NW, Edmonton, Alberta T6G 2M9, Canada.

Funding

CMC Microsystems 6067Natural Sciences and Engineering Research Council of Canada 06630Novocure LLC TTF-01
6 · The paper itself

Abstract

Microtubules are hollow cylindrical polymers composed of the highly negatively-charged (~23e), high dipole moment (1750 D) protein α, β- tubulin. While the roles of microtubules in chromosomal segregation, macromolecular transport, and cell migration are relatively well-understood, studies on the electrical properties of microtubules have only recently gained strong interest. Here, we show that while microtubules at physiological concentrations increase solution capacitance, free tubulin has no appreciable effect. Further, we observed a decrease in electrical resistance of solution, with charge transport peaking between 20-60 Hz in the presence of microtubules, consistent with recent findings that microtubules exhibit electric oscillations at such low frequencies. We were able to quantify the capacitance and resistance of the microtubules (MT) network at physiological tubulin concentrations to be 1.27 × 10

Indexed as

bioelectricitybionanowirescytoskeletonimpedance spectroscopymicrotubulesneuronal charge storage

Identifiers

PMID32033331
PMCPMC7075204

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.