Evidence map›Paper›PMID 32034038›Full record

ReviewThe Journal of experimental biology2020

Recent advances in functional genomics for parasitic nematodes of mammals.

Michelle L Castelletto, Spencer S Gang, Elissa A Hallem

Open access · bronzeAbstract readReview
In one paragraph

Review in The Journal of experimental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
1.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Advances in Anthelmintic Target Identification.International journal of molecular sciences · 2025
    Review
  7. Article
  8. Article
  9. Inference of Essential Genes of the ParasiteInternational journal of molecular sciences · 2024
    Article
  10. Review
  11. Introduction toJournal of nematology · 2024
    Article
  12. A standard workflow for community-driven manual curation ofPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Article
  13. Invade or die: behaviours and biochemical mechanisms that drive skin penetration inPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Review
  14. AdvancingPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Gene editing in the nematode parasiteFrontiers in parasitology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Michelle L CastellettoDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Spencer S GangDivision of Biological Sciences, University of California, San Diego, La Jolla, CA 92161, USA.
Elissa A HallemDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA ehallem@ucla.edu.ORCID 0000-0003-0260-3174
University of California, Los Angeles · USUniversity of California San Diego · US

Funding

The neural basis of odor-driven behavior in skin-penetrating parasitic nematodes.DP2DC014596 · NIDCD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HALLEM, ELISSA ANYON · 2014 to 2014
$2.3M
Howard Hughes Medical InstituteNIDCD NIH HHS DP2 DC014596
6 · The paper itself

Abstract

Human-parasitic nematodes infect over a quarter of the world's population and are a major cause of morbidity in low-resource settings. Currently available treatments have not been sufficient to eliminate infections in endemic areas, and drug resistance is an increasing concern, making new treatment options a priority. The development of new treatments requires an improved understanding of the basic biology of these nematodes. Specifically, a better understanding of parasitic nematode development, reproduction and behavior may yield novel drug targets or new opportunities for intervention such as repellents or traps. Until recently, our ability to study parasitic nematode biology was limited because few tools were available for their genetic manipulation. This is now changing as a result of recent advances in the large-scale sequencing of nematode genomes and the development of new techniques for their genetic manipulation. Notably, skin-penetrating gastrointestinal nematodes in the genus

Indexed as

NematodaAnimalsGene Transfer TechniquesGenomicsHumansMammalsRNA InterferenceCRISPRParasitic helminthParasitic nematodeRNAiStrongyloidesTransgenesis

Identifiers

PMID32034038
PMCPMC7790190
OpenAlexW3004545307

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.